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Table 1 Major characteristics of the included studies

From: Compared efficacy of clopidogrel and ticagrelor in treating acute coronary syndrome: a meta-analysis

Study Publication year Study design No. Patients Drug Dose Follow-up, mo Clinical Outcome
Ticagrelor Clopidogrel Ticagrelor, mg.q.d Clopidogrel, mg.q.d
Cannon 2007 RCT 6732 6676 90 mg.bid LD: 300 MD: 75 3 1、2、3、4
Lars Wallentin 2009 RCT 9333 9291 LD: 180 mg.bid MD: 90 mg.bid LD: 300–600 MD: 75 12 1、2、3、4
Cannon 2010 RCT 663 327 LD: 180 mg.bid MD: 90 mg.bid LD: 300 MD: 75 12 1、2、3
Laurent Bonello 2014 RCT 30 30 LD: 180 mg.bid MD: 90 mg.bid LD: 600 MD: 75 N 4
Y. Hiasa 2014 RCT 93 46 90/45 mg.bid 75 3 3
Shinya Goto 2015 RCT 401 400 LD: 180 mg.bid MD: 90 mg.bid LD: 300 MD: 75 12 1、2、3
Huidong Wang 2016 RCT 100 100 LD: 180 mg.bid MD: 90 mg.bid LD: 300 MD: 75 12 1、2、3
Ran Xiong 2015 RCT 112 112 LD: 180 mg.bid MD: 90 mg.bid LD: 600 MD: 150 12 1
I-Chih Chen 2016 PSM 224 224 / / 12 1、2、3、4
Cheng-Han Lee 2018 PSM 2389 19,112 LD: 180 mg.bid MD: 90 mg.bid LD: 300–600 MD: 75 18 1、2、3
  1. RCT random control trial, PSM propensity score matching, LD loading dose, MD maintenance dose
  2. Outcome [1]: MI [2]; stroke [3]; TIMI-defined bleeding [4]; Dyspnea