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Table 5 Determinants of statin use in secondary prevention (mixed-effect logistic regression)

From: Time trends in statin use and incidence of recurrent cardiovascular events in secondary prevention between 1999 and 2013: a registry-based study

Variables Multivariable analysis (50–59 years) Multivariable analysis (60–79 years) Multivariable analysis (80+ years)
OR [95%CI] p-value OR [95% CI] p-value OR [95% CI] p-value
Baseline characteristics
 Age, per year increase    1.25 [1.02; 1.52] 0.030 0.87 [0.84; 0.90] < 0.001
 Women 0.59 [0.42; 0.84] 0.003 0.64 [0.54; 0.77] < 0.001 0.68 [0.51; 0.89] 0.005
 LDL measurement    0.64 [0.49; 0.83] 0.001 0.50 [0.37; 0.68] < 0.001
Type of CVD history
 MI    1.42 [1.15; 1.75] 0.001   
 IHD without angina    1.40 [1.12; 1.75] 0.003 1.48 [1.06; 2.09] 0.022
 IHD with angina 1.60 [1.04; 2.45] 0.030    1.36 [1.03; 1.80] 0.033
Comorbidities
 Atrial fibrillation      0.66 [0.48; 0.92] 0.013
 Hypercholesterolemia 3.59 [2.45; 5.30] < 0.001 2.40 [1.98; 2.92] < 0.001 2.93 [2.18; 3.97] < 0.001
 Hypertension 0.65 [0.44; 0.96] 0.030 0.58 [0.48; 0.70] < 0.001 0.65 [2.18; 3.97] 0.002
 Mental disorder      0.63 [0.43; 0.91] 0.015
Co-medications
Aspirin and antihypertensive agents
 Reference: Aspirin + RAS and 1.00   1.00   1.00  
 Non-RAS       
 Aspirin + RAS or Non-RAS 0.63 [0.28; 1.35] 0.236 0.61 [0.44; 0.85] 0.004 0.67 [0.40; 1.12] 0.126
 Aspirin alone 0.48 [0.19; 1.19] 0.110 0.23 [0.15; 0.36] < 0.001 0.30 [0.13; 0.71] 0.006
 RAS or Non-RAS 0.15 [0.08; 0.28] < 0.001 0.36 [0.27; 0.47] < 0.001 0.37 [0.24; 0.57] < 0.001
 None of these 3 categories 0.03 [0.01; 0.06] < 0.001 0.04 [0.03; 0.05] < 0.001 0.02 [0.01; 0.03] < 0.001
 Other lipid lowering medication 0.39 [0.17; 0.88] 0.024 0.24 [0.17; 0.35] < 0.001 0.19 [0.08; 0.42] < 0.001
Charlson comorbidity index
 mCCI indexa    0.89 [0.83; 0.95] < 0.001   
 Liver disease      0.54 [0.28; 1.00] 0.054
 Diabetes, mellitus    1.52 [1.22; 1.88] < 0.001   
 Paralysis 5.12 [1.51; 17.60] 0.009     
 Cancer 0.63 [0.39; 1.01] 0.059     
Renal insufficiency
 Yes 1.88 [0.53; 6.60] 0.318 0.98 [0.65; 1.46] 0.904   
 Not measured 0.34 [0.20; 0.55] < 0.001 0.39 [0.27; 0.55] < 0.001   
  1. OR odds ratio, CI confidence interval, LDL low-density lipoprotein, CVD cardiovascular disease, MI myocardial infarction, IHD ischemic heart disease, RAS renin-angiotensin system, mCCI modified Charlson comorbidity index
  2. aMissing kidney function is treated as a score of 0