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Table 7 The rs7396366 polymorphism and other risk factors in 1-, 2-, and 3-vessel lesion patients compared with controls

From: A genetic variant near adaptor-related protein complex 2 alpha 2 subunit gene is associated with coronary artery disease in a Chinese population

Variables One-vessel disease Two-vessel disease Three-vessel disease
OR (95% CI) P OR (95% CI) P OR (95% CI) P
Age <.001 <.001 <.001
Sex 1.17 (0.81–1.67) .406 2.42 (1.47–3.99) <.001 2.49 (1.47–4.20) <.001
BMI .703 .343 .727
Smoking 1.00 (0.67–1.50) .997 1.39 (0.84–2.30) .230 1.62 (0.97–2.71) .073
Hypertension 1.86 (1.26–2.75) .002 2.48 (1.43–4.30) .001 1.67 (0.99–2.85) .054
Total cholesterol (mmol/L) .848 .215 .018
T2DM 1.47 (0.93–2.33) .115 2.01 (1.15–3.50) .018 3.85 (2.26–6.56) <.001
Fasting plasma glucose (mmol/L) .040 .066 .023
Rs7396366(TT) 1.63 (0.90–2.96) .112 1.58 (0.74–3.38) .280 2.86 (1.45–5.65) .005
Rs7396366 (TT vs. GG) 1.68(0.91–3.10) .103 2.37 (1.05–5.35) .048 2.48 (1.23–5.01) .014
  1. Abbreviations: OR odds ratio, CI confidence interval
  2. Age, BMI, total cholesterol and fasting plasma glucose were compared using the Student t test. Other data were compared using the χ2-test