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Table 3 Association analysis of rs7396366 and rs2526378 genotypes between CAD cases and controls

From: A genetic variant near adaptor-related protein complex 2 alpha 2 subunit gene is associated with coronary artery disease in a Chinese population

Genotypes Control (n = 372) CAD cases (n = 335) OR (95% CI) P Multiple adjusted OR a (95% CI) P
n (%) n (%)
Rs7396366
 GG 206 (55.4) 162 (48.4) 0.76 (0.56–1.02) .062 0.67 (0.47–0.97) .035
 GT 137 (36.8) 127 (37.9) 1.05 (0.77–1.42) .766 1.27 (0.87–1.86) .210
 TT 29 (7.8) 46 (13.7) 1.88 (1.15–3.07) .014 1.58 (0.86–2.89) .142
 Additive model    2.02 (1.21–3.35) .008 1.82 (0.97–3.42) .063
 Dominant model    1.33 (0.99–1.78) .062 1.48 (1.03–2.14) .035
Additive model: TT vs. GG. Dominant model: (TT + GT) vs. GG
Rs2526378
 CC 98 (26.3) 91 (27.2) 0.96 (0.69–1.34) .806 1.02 (0.80–1.50) .912
 CT 157 (42.2) 155 (46.3) 0.85 (0.63–1.14) .277 1.20 (0.85–1.69) .295
 TT 102 (27.4) 70 (20.9) 1.43 (1.01–2.03) .044 0.74 (0.50–1.10) .139
 Additive model    1.35 (0.89–2.05) .155 0.75 (0.44–1.27) .282
 Dominant model    1.07 (0.76–1.50) .698 1.06 (0.70–1.60) .797
Additive model: TT vs. CC. Dominant model: (TT + CT) vs. CC
  1. Abbreviations: OR odds ratio, CI confidence interval. Other abbreviations see in Table 1
  2. aLogistic regression model, adjusted by age, sex, hypertension, diabetes, smoking, BMI, and fasting plasma glucose