A genetic variant near adaptor-related protein complex 2 alpha 2 subunit gene is associated with coronary artery disease in a Chinese population

Table 3 Association analysis of rs7396366 and rs2526378 genotypes between CAD cases and controls

Genotypes	Control (n = 372)	CAD cases (n = 335)	OR (95% CI)	P	Multiple adjusted OR ^a (95% CI)	P
Genotypes	n (%)	n (%)	OR (95% CI)	P	Multiple adjusted OR ^a (95% CI)	P
Rs7396366
GG	206 (55.4)	162 (48.4)	0.76 (0.56–1.02)	.062	0.67 (0.47–0.97)	.035
GT	137 (36.8)	127 (37.9)	1.05 (0.77–1.42)	.766	1.27 (0.87–1.86)	.210
TT	29 (7.8)	46 (13.7)	1.88 (1.15–3.07)	.014	1.58 (0.86–2.89)	.142
Additive model			2.02 (1.21–3.35)	.008	1.82 (0.97–3.42)	.063
Dominant model			1.33 (0.99–1.78)	.062	1.48 (1.03–2.14)	.035
Additive model: TT vs. GG. Dominant model: (TT + GT) vs. GG
Rs2526378
CC	98 (26.3)	91 (27.2)	0.96 (0.69–1.34)	.806	1.02 (0.80–1.50)	.912
CT	157 (42.2)	155 (46.3)	0.85 (0.63–1.14)	.277	1.20 (0.85–1.69)	.295
TT	102 (27.4)	70 (20.9)	1.43 (1.01–2.03)	.044	0.74 (0.50–1.10)	.139
Additive model			1.35 (0.89–2.05)	.155	0.75 (0.44–1.27)	.282
Dominant model			1.07 (0.76–1.50)	.698	1.06 (0.70–1.60)	.797
Additive model: TT vs. CC. Dominant model: (TT + CT) vs. CC

Abbreviations: OR odds ratio, CI confidence interval. Other abbreviations see in Table 1
^aLogistic regression model, adjusted by age, sex, hypertension, diabetes, smoking, BMI, and fasting plasma glucose

ISSN: 1471-2261