Table 1 Inclusion and exclusion criteria

• Age ≥ 70 years

• Hospital admission for acute coronary syndrome (ACS) and coronary artery angiography ± percutaneous coronary intervention

ACS is defined in presence of the following criteria (the first mandatory and at least one between criterion 2 and 3):

1. Chest pain suggestive of cardiac origin lasting at least 20 min

2. ECG changes compatibles with signs of myocardial ischemia

3. Detection of rise of cardiac biomarkers

• Informed consent

• SPPB score 4–9 at the inclusion visit (T1)

• Short portable mental status questionnaire (SPMSQ) < 4

SPMSQ is performed as first test. If it results less than 4 the patient is excluded

• Life expectancy < 12 months

• The patient is not discharged at home, but he/she is transferred from the cardiology unit to other hospital unit or community structure

• Chronic heart failure NYHA III-IV.

• Left ventricle ejection fraction < 30%.

• Severe aortic or mitral valvulopathy

• Multivessel coronary artery disease or left main coronary artery disease candidate to CABG

• Planned staged PCI

• Impossibility to perform physical activity due to physical impairment