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Table 1 Two-way ANOVA statistics with Bonferroni correction at base (T1), before injection (T2) and after injection (T3) for all sham animals (n = 4)

From: Effects of the cardiac myosin activator Omecamtiv-mecarbil on severe chronic aortic regurgitation in Wistar rats

 

T1

T2

p

T3

p

Heart Rate (beats/min)

258 ± 11

270 ± 7

0,756

193 ± 15

0,251

Left Atrium (mm)

4.6 ±  0.2

6.2 ±  0.3

0,872

5.5 ± 0.2

0,118

LVEDD (mm)

7.9 ± 0.5

11.1 ± 0.4

0,938

10.1 ± 0.5

0,209

LVESD (mm)

5.5 ± 0.4

7.6 ± 0.3

0,736

6.1 ± 0.4

0,072

FS (%)

31.5 ± 1.4

30.5 ± 1.0

0,937

35.4 ± 1.5

0,011

EF (%)

64.1 ± 2.0

63.9 ± 1.4

0,630

68.8 ± 2.5

0,032

Stroke Volume (ml)

0.34 ± 0.03

0.22 ± 0.18

0,448

0.30 ± 0.04

0,762

Cardiac Output (ml/min)

79.5 ± 9.3

52.0 ± 4.5

0,890

61.6 ± 8.6

0,393

SWTs (mm)

2.1 ± 0.1

2.3 ± 0.2

0,671

2.7 ± 0.2

0,457

SWTd (mm)

1.4 ± 0.1

1.7 ± 0.2

0,971

2.1 ± 0.2

0,092

Systolic time (ms)

126 ± 3.7

134 ± 2.6

0,245

135 ± 2.6

0,153

Diastolic time (ms)

139 ± 8.4

135 ± 8.3

0,207

157 ± 14.5

0,138

PEP (ms)

15.0 ± 1.6

25.4 ± 1.3

0,413

21.8 ± 1.0

0,308

LVET (ms)

110 ± 4.4

109 ± 2.8

0,310

113 ± 3.9

0,268

PEP/LVET

0.13 + 0.02

0.23 + 0.02

0,800

0.19 + 0.01

0,968

Systolic time/RR

0.48 + 0.02

0.50 + 0.02

0,344

0.47 + 0.02

0,370

  1. Values are mean ± SD. LVEDD Left ventricle end-diastolic diameter, LVEDV Left ventricle end-diastolic volume, LVESD Left ventricle end-systolic diameter, LVESD Left ventricle end-systolic volume, FS Fractional shortening, EF Ejection fraction, SV stroke volume, SWTs septal wall thickness at end-systole, SWTd septal wall thickness at end-diastole, PEP aortic pre-ejection period, LVET Left ventricular ejection time, RR inter-beat interval
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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