Fig. 1

The atherosclerotic plaque area was decreased in the AS+PHPS1 group. Ldlr^−/− mice were fed a high-fat diet for 4 weeks. Mice in the AS+PHPS1 group were intraperitoneally injected with 3 mg/kg PHPS1 at the indicated time, and those in the AS+Vehicle group were injected with saline containing 0.5% DMSO. a Images of the aortic arch of Ldlr^−/− mice in the AS, AS+PHPS1 and AS+Vehicle groups. b Left: representative en face images of the Oil Red O-stained whole aorta of Ldlr^−/− mice. Right: quantification of the plaque area as a percentage of the aortic surface in Ldlr^−/− mice. Data are presented as the mean ± SE (n = 10 per group). *p < 0.05 vs. the AS group