Treatment Patterns (ACEI, ARB, or BB)a | Treatment Patterns (Diuretic)a | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Increase (n = 36,478)b | No changes (n = 507,371) | Decrease (n = 34,091) | Rate Ratio for Treatment Increase | Rate Ratio for Treatment Decrease | No to Yes (n = 22,015) | No changes (n = 537,855) | Yes to No (n = 19,276) | Rate Ratio for Treatment Increase | Rate Ratio for Treatment Decrease | |
NYHA class change, %c | ||||||||||
Increase (n = 8452) | 8.1 | 83.8 | 7.8 | 1.5 | 1.3 | 6.1 | 89.8 | 4.0 | 1.9 | 1.1 |
No changes (n = 156,801) | 5.5 | 88.3 | 6.0 | – | – | 3.3 | 93.2 | 3.5 | – | – |
Decrease (n = 8370) | 7.7 | 85.1 | 7.1 | 1.4 | 1.2 | 4.5 | 91.9 | 3.7 | 1.4 | 1.1 |
Dyspnea change, %c | ||||||||||
No to yes (n = 20,833) | 14.5 | 80.4 | 4.8 | 2.5 | 0.9 | 9.2 | 88.0 | 2.8 | 2.6 | 0.9 |
No changes (n = 435,120) | 5.8 | 88.6 | 5.4 | – | – | 3.6 | 93.3 | 3.2 | – | – |
Yes to no (n = 13,026) | 4.3 | 83.8 | 11.6 | 0.7 | 2.2 | 2.7 | 92.2 | 5.1 | 0.8 | 1.6 |
Orthopnea change, %c | ||||||||||
No to yes (n = 10,720) | 13.4 | 82.0 | 4.5 | 2.2 | 0.8 | 8.7 | 88.5 | 2.8 | 2.4 | 0.8 |
No changes (n = 463,734) | 6.0 | 88.1 | 5.7 | – | – | 3.7 | 93.0 | 3.3 | – | – |
Yes to no (n = 7659) | 4.2 | 87.3 | 8.4 | 0.7 | 1.5 | 2.8 | 92.7 | 4.5 | 0.8 | 1.4 |
Changes in signs, %c,d | ||||||||||
Increase (n = 24,634) | 14.0 | 79.4 | 6.3 | 2.4 | 1.1 | 9.6 | 87.0 | 3.5 | 2.7 | 1.0 |
No changes (n = 275,342) | 5.9 | 88.2 | 5.7 | – | – | 3.5 | 93.1 | 3.4 | – | – |
Decrease (n = 18,282) | 5.5 | 85.5 | 8.6 | 0.9 | 1.5 | 3.3 | 91.8 | 4.9 | 0.9 | 1.4 |