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Table 1 Demographics, CPET and PFT parameters

From: Characteristics of exercise capacity in female systemic lupus erythematosus associated pulmonary arterial hypertension patients

 

SLE PAH (n = 21)

IPAH (n = 21)

Control (n = 21)

Demographics

Age, years

39.9 ± 9.6

36.7 ± 10.9

41.4 ± 12.8

Gender, F/M

21/0

21/0

21/0

Height, cm

157 ± 4.1

160 ± 7.2

159 ± 4.9

Weight, kg

53.8 ± 7.2

57.6 ± 9.2

57.7 ± 6.2

Body mass index(BMI), kg/m2

22.0 ± 2.9

21.1 ± 6.0

22.8 ± 2.6

CPET parameters

Peak work load, W (%pred)

68.9 ± 22.9**

76.8 ± 23.1**

117.6 ± 21.1

(66.3 ± 23.6)**

(54.0 ± 24.0)**

(108.4 ± 34.2)

Peak VO2,ml/min (%pred)

766 ± 258**

903 ± 207**

1335 ± 232

(55.1 ± 18)**

(47.9 ± 22)**

(95.0 ± 40)

Peak VO2, ml/min/kg

14.4 ± 4.9**

16.0 ± 3.5**

23.4 ± 4.3

Peak VCO2, ml/min

895.8 ± 333.1**

978.5 ± 269.8**

1549.1 ± 296.6

Peak HR, beats/min

147.3 ± 19.7

144.2 ± 26.1**

161.7 ± 18.1

Peak O2 pulse, ml/beat

5.2 ± 1.3**#

6.4 ± 1.6**#

8.2 ± 1.1

Peak VE, L/min

40.1 ± 10.8

46.4 ± 14.0

48.30 ± 11.8

Peak VO2/VE, ml/l

19.6 ± 4.6**

20.4 ± 5.1**

28.4 ± 4.8

Peak PETCO2, mmHg

26.9 ± 6.9**

25.46 ± 7.7**

37.5 ± 5.5

VO2AT, ml/min (%pred)

554 ± 182**#

678 ± 156**#

896 ± 171

(53.9 ± 16.2)**

(57.3 ± 16.4)**

(85.9 ± 30.1)

AT O2 pulse, ml/beat

4.6 ± 1.1**

6.6 ± 3.9#

7.2 ± 1.4

Lowest VE/VCO2 (%pred)

44.7 ± 13.8**

43.56 ± 11.25**

29.74 ± 3.2

(178.4 ± 57.1)**

(167.0 ± 42.6)**

(108.8 ± 13.4)

VE /VCO2 Slope (%pred)

50.3 ± 28.9**

47.6 ± 17.4**

27.6 ± 4.3

161.6 ± 92.6**

162.4 ± 71.6**

90.2 ± 16.1

OUES, L/min/log(L/min) (%pred)

0.96 ± 0.29**

0.97 ± 0.34**

1.76 ± 0.41

(62.5 ± 19.2)**

(50.6 ± 26.5)**

(119.6 ± 61.8)

OUEP, ml/L (%pred)

26.2 ± 5.2**

27.2 ± 5.5**

37.5 ± 4.2

(70.2 ± 12.8)**

(68.5 ± 14.2)**

(101.7 ± 13.3)

RER

0.89 ± 0.08

0.86 ± 0.07

0.84 ± 0.08

Pulmonary function test parameters

Parameter

SLE PAH

IPAH

Control

FVC, L (%pred)

2.23 ± 0.6**#

2.80 ± 0.7*#

2.86 ± 0.5

(72.1 ± 16.9)**

(79.0 ± 12.0)*

(92.5 ± 17.6)

FEV1, L (%pred)

1.86 ± 0.56**

2.28 ± 0.61*

2.44 ± 0.45

(70.8 ± 17.3)*

(75.1 ± 12.0)**

(91.2 ± 11.3)

FEV1/FVC (%)

83.7 ± 6.4

81.1 ± 8.1

85.9 ± 6.6

MVV, L/min (%pred)

56.2 ± 20.6**

86.0 ± 25.1

77.9 ± 15.9

(66.8 ± 23.6)**

(98.0 ± 19.0)*

(89.4 ± 18.1)

DLCO, ml/mmHg/min (%pred)

12.7 ± 3.4**#

17.1 ± 5.0#

19.2 ± 3.9

(65.7 ± 16.7)**#

(85.2 ± 22.4)#

(90.9 ± 11.6)

TLC, L (%pred)

3.8 ± 0.9**#

4.6 ± 0.7#

4.6 ± 0.5

(85.9 ± 14.4)*

(91.0 ± 10.0)

(96.9 ± 9.6)

  1. PFT pulmonary function test, FVC% percent of predicted forced vital capacity, FEV1% percent of predicted forced expiratory volume in 1 s, DLco% percent of predicted gas transfer index or diffusing capacity for carbon monoxide, MVV minute ventilation volume, TLC total lung capacity, CPET cardiopulmonary exercise testing, VO2 oxygen uptake per minute, O2 pulse oxygen pulse, PETO2 partial pressure of end-tidal oxygen, PETCO2 partial pressure of end-tidal carbon dioxide, OUEP oxygen uptake efficiency plateau, OUES oxygen uptake efficiency slope, AT anaerobic threshold, RER reserve expiratory ratio
  2. *p < 0.05, **p < 0.005, between SLE PAH, IPAH Vs control; #p < 0.05 between SLE PAH and IPAH
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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