Table 2 GRADE assessment of confidence in estimates of effect in randomized trials
Outcome | No. of participants (trials) | Risk of bias | Consistency | Directness | Precision | Publication bias | Quality | Odds ratio (95% CI) |
|---|---|---|---|---|---|---|---|---|
Composite outcome | 2776 (4) | No serious limitations | No serious limitations | Serious limitations§ | No serious limitations | Not detected | Moderate | 0.62 (0.44, 0.88) |
Recurrent ischemic stroke | 3440 (5) | No serious limitations | Serious limitations†| No serious limitations | No serious limitations | Not detected | Moderate | 0.41 (0.19, 0.89) |
TIA | 3336 (5) | No serious limitations | No serious limitations | No serious limitations | Serious limitations¶ | Not detected | Moderate | 0.81 (0.56, 1.17) |
All-cause death | 3391 (5) | No serious limitations | No serious limitations | No serious limitations | Serious limitations¶ | Not detected | Moderate | 0.84 (0.40, 1.74) |
Atrial fibrillation or atrial flutter | 3391 (5) | No serious limitations | No serious limitations‡ | No serious limitations | No serious limitations | Not detected | High | 5.74 (3.08, 10.70) |
Pulmonary embolism | 2531 (4) | No serious limitations | No serious limitations | No serious limitations | Serious limitations¶ | Not detected | Moderate | 3.03 (1.06, 8.63) |
Major bleeding | 3283 (5) | No serious limitations | No serious limitations‡ | Serious limitations§ | Serious limitations¶ | Not detected | Low | 1.01 (0.55, 1.86) |