Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) rs1558139, rs2108622 polymorphisms and susceptibility to several cardiovascular and cerebrovascular diseases

Table 1 Meta-analysis of CYP4AF2 rs1558139 C/T polymorphism

Genetic models	Subgroup	Test of association			N	Sample size		Heterogeneity
Genetic models	Subgroup	OR (95% CIs)	z	P value	N	case	control	I²	P value
allele (T vs. C)	overall/Asian	0.92 (0.86, 0.99)	2.31	0.021	10	3462	3547	0.0%	0.931
	hypertension	0.89 (0.81, 0.98)	2.34	0.019	4	1852	1787	0.0%	0.768
	CAD	1.00 (0.87, 1.14)	0.05	0.963	3	883	914	0.0%	0.685
	population-based	0.91 (0.85, 0.98)	2.49	0.013	8	2927	3033	0.0%	0.967
homozygote (TT vs. CC)	overall	0.87 (0.76, 1.00)	1.89	0.058	10	3462	3547	0.0%	0.955
	hypertension	0.85 (0.70, 1.04)	1.59	0.111	4	1852	1787	0.0%	0.900
	CAD	0.99 (0.76, 1.30)	0.05	0.963	3	883	914	0.0%	0.609
	population-based	0.85 (0.70, 1.04)	1.99	0.047	8	2927	3033	0.0%	0.991
heterozygote (CT vs. CC)	overall/Asian	0.89 (0.80, 0.98)	2.26	0.024	10	3462	3547	0.0%	0.738
	hypertension	0.81 (0.70, 0.93)	2.95	0.003	4	1852	1787	0.0%	0.565
	CAD	0.98 (0.79, 1.21)	0.18	0.857	3	883	914	0.0%	0.977
	population-based	0.87 (0.78, 0.97)	2.46	0.014	8	2927	3033	0.0%	0.662
dominant (CT + TT vs. CC)	overall	0.88 (0.80, 0.97)	2.53	0.012	10	3462	3547	0.0%	0.866
	hypertension	0.82 (0.71, 0.93)	2.95	0.003	4	1852	1787	0.0%	0.650
	CAD	0.98 (0.80, 1.20)	0.16	0.871	3	883	914	0.0%	0.952
	population-based	0.86 (0.78, 0.96)	2.71	0.007	8	2927	3033	0.0%	0.821
recessive (TT vs. CC + CT)	overall/Asian	0.93 (0.82, 1.06)	1.03	0.303	10	3462	3547	0.0%	0.889
	hypertension	0.95 (0.80, 1.14)	0.52	0.601	4	1852	1787	0.0%	0.898
	CAD	1.01 (0.80, 1.28)	0.11	0.914	3	883	914	0.0%	0.483
	population-based	0.92 (0.80, 1.06)	1.14	0.256	8	2927	3033	0.0%	0.977

OR odds ratio, CIs confidence intervals, CAD coronary artery disease, N number of case-control studies

ISSN: 1471-2261