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Table 1 Meta-analysis of CYP4AF2 rs1558139 C/T polymorphism

From: Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) rs1558139, rs2108622 polymorphisms and susceptibility to several cardiovascular and cerebrovascular diseases

Genetic models Subgroup Test of association N Sample size Heterogeneity
OR (95% CIs) z P value case control I2 P value
allele (T vs. C) overall/Asian 0.92 (0.86, 0.99) 2.31 0.021 10 3462 3547 0.0% 0.931
hypertension 0.89 (0.81, 0.98) 2.34 0.019 4 1852 1787 0.0% 0.768
CAD 1.00 (0.87, 1.14) 0.05 0.963 3 883 914 0.0% 0.685
population-based 0.91 (0.85, 0.98) 2.49 0.013 8 2927 3033 0.0% 0.967
homozygote (TT vs. CC) overall 0.87 (0.76, 1.00) 1.89 0.058 10 3462 3547 0.0% 0.955
hypertension 0.85 (0.70, 1.04) 1.59 0.111 4 1852 1787 0.0% 0.900
CAD 0.99 (0.76, 1.30) 0.05 0.963 3 883 914 0.0% 0.609
population-based 0.85 (0.70, 1.04) 1.99 0.047 8 2927 3033 0.0% 0.991
heterozygote (CT vs. CC) overall/Asian 0.89 (0.80, 0.98) 2.26 0.024 10 3462 3547 0.0% 0.738
hypertension 0.81 (0.70, 0.93) 2.95 0.003 4 1852 1787 0.0% 0.565
CAD 0.98 (0.79, 1.21) 0.18 0.857 3 883 914 0.0% 0.977
population-based 0.87 (0.78, 0.97) 2.46 0.014 8 2927 3033 0.0% 0.662
dominant (CT + TT vs. CC) overall 0.88 (0.80, 0.97) 2.53 0.012 10 3462 3547 0.0% 0.866
hypertension 0.82 (0.71, 0.93) 2.95 0.003 4 1852 1787 0.0% 0.650
CAD 0.98 (0.80, 1.20) 0.16 0.871 3 883 914 0.0% 0.952
population-based 0.86 (0.78, 0.96) 2.71 0.007 8 2927 3033 0.0% 0.821
recessive (TT vs. CC + CT) overall/Asian 0.93 (0.82, 1.06) 1.03 0.303 10 3462 3547 0.0% 0.889
hypertension 0.95 (0.80, 1.14) 0.52 0.601 4 1852 1787 0.0% 0.898
CAD 1.01 (0.80, 1.28) 0.11 0.914 3 883 914 0.0% 0.483
population-based 0.92 (0.80, 1.06) 1.14 0.256 8 2927 3033 0.0% 0.977
  1. OR odds ratio, CIs confidence intervals, CAD coronary artery disease, N number of case-control studies