Table 1 Demographic and clinical characteristics of the propensity-matched cohort
Characteristics | Total (n = 20,067) | Adults a (n = 6689) | Elderly b (n = 6689) | Very elderly c (n = 6689) | p value* | Post hoc† |
|---|---|---|---|---|---|---|
Age, years, mean (SD) | 68.5 (15.2) | 50.4 (9.0) | 70.9 (4.1) | 84.3 (4.0) | <0.0001 | a < b < c |
Sex, male, n (%) | 5502 (27.4) | 1834 (27.4) | 1834 (27.4) | 1834 (27.4) | 1.000 | |
Charlson comorbidity index score, mean (SD) | 0.5 (0.9) | 0.5 (0.9) | 0.5 (0.8) | 0.5 (0.9) | 0.948 | |
0 | 12,780 (63.7) | 4258 (63.7) | 4264 (63.8) | 4258 (63.7) | 1.000 | |
≥ 1 | 7287 (36.3) | 2431 (36.3) | 2425 (36.3) | 2431 (36.3) | 0.992 | |
Health insurance type | ||||||
Health insurance | 18,621 (92.8) | 6207 (92.8) | 6207 (92.8) | 6207 (92.8) | 1 | |
Medical aid | 1446 (7.2) | 482 (7.2) | 482 (7.2) | 482 (7.2) | ||
Number of concomitant medications, mean (SD) | 3.3 (2.8) | 2.7 (2.4) | 3.4 (2.8) | 3.7 (3.0) | <0.0001 | a < b < c |
Underlying disease, n (%) | ||||||
Dementia | 277 (2.1) | 24 (0.2) | 59 (0.9) | 194 (2.9) | <0.0001 | a < b < c |
Depression | 639 (4.6) | 440 (3.2) | 104 (1.6) | 95 (1.4) | <0.0001 | a > b,c |
Dyslipidemia | 2496 (16.3) | 1963 (12.8) | 366 (5.5) | 167 (2.5) | <0.0001 | a > b > c |
Therapeutic class of index therapy, n (%) | ||||||
Dihydropyridine calcium channel blockers | 9807 (48.9) | 2619 (39.2) | 3374 (50.4) | 3814 (57.0) | <0.0001 | <0.0001 |
Angiotensin receptor blockers | 6419 (32.0) | 2722 (40.7) | 2077 (31.1) | 1620 (24.2) | ||
Selective beta blockers | 2009 (10.0) | 900 (13.5) | 620 (9.3) | 489 (7.3) | ||
Thiazide type diuretics | 1212 (6.0) | 324 (4.8) | 412 (6.2) | 476 (7.1) | ||
Alpha blockers | 359 (1.8) | 29 (0.4) | 128 (1.9) | 202 (3.0) | ||
Angiotensin converting enzyme inhibitors | 250 (1.2) | 84 (1.3) | 78 (1.2) | 88 (1.3) | ||
Others | 11 (0.1) | 11 (0.2) | 0 (0.0) | 0 (0.0) | ||