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Table 1 Demographic and clinical characteristics of the propensity-matched cohort

From: Persistence with antihypertensives in uncomplicated treatment-naïve very elderly patients: a nationwide population-based study

Characteristics Total (n = 20,067) Adults a (n = 6689) Elderly b (n = 6689) Very elderly c (n = 6689) p value* Post hoc
Age, years, mean (SD) 68.5 (15.2) 50.4 (9.0) 70.9 (4.1) 84.3 (4.0) <0.0001 a < b < c
Sex, male, n (%) 5502 (27.4) 1834 (27.4) 1834 (27.4) 1834 (27.4) 1.000  
Charlson comorbidity index score, mean (SD) 0.5 (0.9) 0.5 (0.9) 0.5 (0.8) 0.5 (0.9) 0.948  
 0 12,780 (63.7) 4258 (63.7) 4264 (63.8) 4258 (63.7) 1.000  
 ≥ 1 7287 (36.3) 2431 (36.3) 2425 (36.3) 2431 (36.3) 0.992  
Health insurance type
 Health insurance 18,621 (92.8) 6207 (92.8) 6207 (92.8) 6207 (92.8) 1  
 Medical aid 1446 (7.2) 482 (7.2) 482 (7.2) 482 (7.2)   
 Number of concomitant medications, mean (SD) 3.3 (2.8) 2.7 (2.4) 3.4 (2.8) 3.7 (3.0) <0.0001 a < b < c
Underlying disease, n (%)
 Dementia 277 (2.1) 24 (0.2) 59 (0.9) 194 (2.9) <0.0001 a < b < c
 Depression 639 (4.6) 440 (3.2) 104 (1.6) 95 (1.4) <0.0001 a > b,c
 Dyslipidemia 2496 (16.3) 1963 (12.8) 366 (5.5) 167 (2.5) <0.0001 a > b > c
Therapeutic class of index therapy, n (%)
 Dihydropyridine calcium channel blockers 9807 (48.9) 2619 (39.2) 3374 (50.4) 3814 (57.0) <0.0001 <0.0001
 Angiotensin receptor blockers 6419 (32.0) 2722 (40.7) 2077 (31.1) 1620 (24.2)   
 Selective beta blockers 2009 (10.0) 900 (13.5) 620 (9.3) 489 (7.3)   
 Thiazide type diuretics 1212 (6.0) 324 (4.8) 412 (6.2) 476 (7.1)   
 Alpha blockers 359 (1.8) 29 (0.4) 128 (1.9) 202 (3.0)   
 Angiotensin converting enzyme inhibitors 250 (1.2) 84 (1.3) 78 (1.2) 88 (1.3)   
 Others 11 (0.1) 11 (0.2) 0 (0.0) 0 (0.0)   
  1. *Analysis of variance test or chi-squared test of the three groups
  2. Bonferroni correction (p < 0.015) with student’s t-test or chi-squared test
  3. aAdult cohort bElderly cohort cVery elderly cohort