Fig. 3

Scoring analysis of miRs and their target genes in cardiovascular and metabolic diseases following the procedure of Fig. 2. a-b MiR were scored and scores were ranked from highest to lowest on a disease group level for all cardiovascular (a) and metabolic diseases (b). Strikingly, with exception of miR-122, which was found upregulated (positive score), and −223 which was counter regulated between both disease groups, no overlap in the depicted miRs was found between both disease groups, allowing for differential markers. c-e MiR scores were calculated for (c) Coronary Artery Disease, (d) Acute Coronary Syndrome and (e) Heart Failure following the procedure of Fig. 2 and ranked according an overall importance from top till bottom as stated in the text. The highest positive and negative scores for each condition were given. While scores for CAD and were found to be more equally distributed between positive and negative numbers, miRs related to ACS had mainly positive scores, indicating a general up-regulation of the miR transcriptome. Analysing miR scores between the three above three conditions revealed miR-1, miR-208a and miR-133a to distinguish ACS and CAD form HF