Table 1 Characteristics of studies included in the meta-analysis
Author | Year | Country | Ethnicity | Disease | Etiology of HF | Genotyping methods | Total number | Number | Gender (M/F) | Age (Year) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CC | CT + TT | CC | CT + TT | CC | CT + TT | ||||||||
Tousoulis D [10] | 2014 | Greece | Caucasian | Consecutive stable CAD | PCR-RFLP | 192 | 149 | 43 | 90/10 | 93/7 | 61 ± 11 | 61 ± 11 | |
Safranow K_a [21] | 2009 | Poland | Caucasian | Stable CAD with HF | Ischemic (67%); Non-ischemic (22%); Other factors (11%) | PCR-RFLP | 97 | 68 | 29 | 55/19 | 27/3 | 59.92 ± 8.26 | 56.4 ± 12.0 |
Safranow K_b [21] | 2009 | Poland | Caucasian | Stable CAD without HF | PCR-RFLP | 104 | 74 | 30 | 55/13 | 20/9 | 58.3 ± 8.6 | 57.9 ± 8.6 | |
de Groote P [15] | 2006 | France | Caucasian | Stable CHF | Ischemic (42.57%); Non-ischemic (57.43%) | PCR-RFLP | 686 | 517 | 169 | 415/102 | 136/33 | 55 ± 13 | 57 ± 13 |
Collins RP [14] | 2006 | New Zealand | Caucasian | HF | Irrespective of etiology | PCR-RFLP | 357 | 279 | 78 | 167/167 | 51/48 | 74.3 ± 0.62 | 75.4 ± 0.95 |
Agewall S [22] | 2006 | Norway | Caucasian | CHD | TaqMan | 109 | 82 | 27 | 64/18 | 18/9 | 61 ± 11 | 62 ± 11 | |
Kolek MJ [23] | 2005 | USA | Mix | HF | Ischemic (58%); Non-ischemic (42%) | PCR-RFLP | 1038 | 843 | 195 | 666/177 | 158/37 | 60.2 ± 12.2 | 61.0 ± 12.0 |
Gastmann A [24] | 2004 | Germany | Caucasian | CHF | Idiopathic dilated cardiomyopathy (58.89%); Coronary artery disease (22.22%); Other factors (18.89%). | Direct sequencing | 90 | 68 | 22 | 51/17 | 16/6 | 57.2 ± 13.2 | 54.0 ± 14.3 |
Loh E [13] | 1999 | USA | Caucasian | CHF | Coronary artery disease (52.27%); Idiopathic cardiomyopathy (36.36%); Other factors (11.36%). | ASO-PCR | 132 | 111 | 21 | 97/14 | 16/5 | 52.1 6 ± 11.6 | 56.86 ± 7.1 |