Pro-Adrenomedullin predicts 10-year all-cause mortality in community-dwelling patients: a prospective cohort study

Table 2 Association between ProADM blood levels at baseline and day 7 and 10-year outcomes

baseline	all-cause mortality	adverse outcome
Unadjusted HR	4.2 (1.5 to 11.5), p = 0.006	1.9 (1.0 to 3.7), p = 0.054
age-adjusted HR	2.5 (1.0 to 6.1), p = 0.043	1.4 (0.8 to 2.5), p = 0.273
age&group adjusted HR	2.7 (1.0 to 7.1), p = 0.047	1.5 (0.8 to 2.8), p = 0.234
age&group&smoking adjusted HR	2.7 (1.0 to 7.1), p = 0.051	1.4 (0.7 to 2.7), p = 0.314
AUC	0.74 (0.54 to 0.94)	0.62 (0.45 to 0.80)
day 7
Unadjusted HR	2.7 (1.0 to 7.4), p = 0.055	1.8 (0.9 to 3.7), p = 0.108
age-adjusted HR	1.7 (0.7 to 4.1), p = 0.282	1.2 (0.6 to 2.5), p = 0.547
age&group adjusted HR	1.8 (0.7 to 4.6), p = 0.245	1.3 (0.6 to 2.6), p = 0.469
age&group&smoking adjusted HR	1.7 (0.7 to 4.6), p = 0.262	1.2 (0.6 to 2.6), p = 0.592
AUC	0.70 (0.48 to 0.92)	0.63 (0.45 to 0.81)

Data for univariable, bivariable and multivariable analyses are given as HR (95% CI) and p value. Data regarding prognostic analysis are given as AUC (95%CI). A higher AUC reflects greater accuracy: 0.5, the null value, indicates coin-tossaccuracy, while 1.0, the maximum value, indicates 100% accuracy. P values in bold type are statistically significant at p < 0.05
Univariable model includes: natural logarithmic value of ProADM blood concentrations
Bivariable model includes: natural logarithmic value of ProADM blood concentrations and patient age

ISSN: 1471-2261