Left atrial appendage morphology and risk of stroke following pulmonary vein isolation for drug-refractory atrial fibrillation in low CHA2DS2Vasc risk patients

Table 3 Volumetric and CT attenuation data in patients with CVA following PVI compared with patients without an observed event

CT Characteristics	Post-PVI CVA	No CVA after PVI	p-value
CT Characteristics	(n = 4)	(n = 328)	p-value
Age	58 ± 11	55 ± 13	0.655
Age ≥ 75 years	0 (0%)	13 (4.0%)	0.682
Male gender	4 (100%)	274 (83.5%)	0.373
HTN	2 (50%)	198 (60.4%)	0.674
CHF	0 (0%)	22 (6.7%)	0.589
DM2	0 (0%)	48 (14.6%)	0.407
Vascular disease	1 (25%)	139 (42.4%)	0.484
Prior CVA/TIA	1 (25%)	15 (4.6%)	0.059
CHA₂DS₂Vasc > 1	1 (25%)	162 (49.4%)	0.332
CHA₂DS₂Vasc, median (IQR)	1 (0, 2.5)	1 (1, 3)	0.543
Anticoagulation
Warfarin	3 (75%)	198 (60.4%)	0.555
NOAC	1 (25%)	87 (26.5%)	0.952
Aspirin	0 (0%)	43 (13.1%)	0.435
Pre-procedure INR*	2.1 ± 0.3	2.2 ± 0.5	0.792
Rhythm prior to PVI
Sinus rhythm	1 (25%)	162 (49.4%)	0.332
Atrial Arrhythmia	2 (50%)	164 (50%)	1.000
Paced	1 (25%)	2 (0.6%)	<0.001
LAA volume	13.9 ± 5.3	13.8 ± 6.0	0.989
LA volume	102.6 ± 18.3	99.5 ± 33.8	0.852
LAA/LA volume	0.13 ± 0.04	0.15 ± 0.06	0.655
LAA HU	372.4 ± 92.6	341.9 ± 77.8	0.438
LA HU	410.6 ± 78.8	357.8 ± 97.0	0.279
LAA/LA HU	0.90 ± 0.08	1.00 ± 0.36	0.594

LAA left atrial appendage, LA left atrium, CVA cerebral vascular accident/stroke, PVI pulmonary vein isolation
All continuous variables are displayed as mean values ± standard deviation. All volumes are displayed in milliliters (mL) and all CT attenuation numbers are displayed in Hounsfield units (HU)
*INR only includes patients treated with coumadin prior to PVI

ISSN: 1471-2261