Variable | 2010 (n = 804) | 2011 (n = 930) | 2012 (n = 1045) | 2013 (n = 1241) | 2014 (n = 1268) | P |
---|---|---|---|---|---|---|
Biochemical | ||||||
TC (mmol/L) | 4.54 ± 1.26 | 4.48 ± 1.16 | 4.44 ± 1.35 | 4.42 ± 1.19 | 4.35 ± 1.26 | 0.020 |
TG (mmol/L) | 3.12 ± 6.26 | 2.23 ± 1.51 | 2.28 ± 1.88 | 2.31 ± 1.89 | 2.49 ± 6.83 | 0.026 |
LDL (mmol/L) | 3.21 ± 8.39 | 2.26 ± 0.96 | 2.75 ± 1.09 | 2.74 ± 1.01 | 2.77 ± 3.26 | NS |
HDL (mmol/L) | 0.99 ± 0.22 | 0.94 ± 0.23 | 0.91 ± 0.21 | 0.89 ± 0.21 | 0.89 ± 0.20 | 0.000 |
Creatinine (mg/dL) | 82.59 ± 34.06 | 78.41 ± 16.91 | 78.83 ± 47.32 | 77.85 ± 45.99 | 77.79 ± 18.38 | 0.030 |
BUN (mmol/L) | 7.61 ± 4.85 | 7.29 ± 4.55 | 7.66 ± 5.17 | 7.51 ± 4.54 | 7.18 ± 4.53 | NS |
UA (μmol/L) | 372.1 ± 111.2 | 355.5 ± 88.9 | 359.9 ± 91.3 | 367.9 ± 93.4 | 380.4 ± 91.9 | 0.000 |
ALT (U/L) | 50.2 ± 48.3 | 45.4 ± 35.2 | 48.6 ± 43.1 | 46.8 ± 41.4 | 48.1 ± 42.0 | NS |
AST (U/L) | 62.3 ± 92.7 | 56.7 ± 89.5 | 52.2 ± 77.2 | 51.2 ± 74.3 | 53.1 ± 77.4 | NS |
CK (U/L) | 386.9 ± 875.3 | 368.3 ± 894.6 | 314.4 ± 737.5 | 336.8 ± 718.7 | 377.7 ± 928.1 | NS |
CKMB (ng/ml) | 33.7 ± 76.1 | 29.4 ± 82.1 | 20.8 ± 60.5 | 26.0 ± 138.1 | 29.5 ± 141.3 | NS |
cTnT (ng/ml) | 1.94 ± 1.43 | 1.82 ± 1.31 | 1.87 ± 1.53 | 1.97 ± 2.23 | 1.95 ± 1.97 | NS |
NT-proBNP (pg/ml) | 657.0 ± 3973.8 | 385.6 ± 1348.7 | 372.8 ± 1638.5 | 206.8 ± 572.4 | 197.0 ± 561.7 | 0.000 |
Glucose (mmol/L) | 6.73 ± 2.89 | 6.45 ± 2.51 | 6.57 ± 2.71 | 6.67 ± 2.68 | 6.56 ± 2.88 | NS |
HbA1c (%) | 6.86 ± 1.76 | 6.64 ± 1.72 | 6.71 ± 1.71 | 6.16 ± 1.70 | 6.36 ± 1.63 | NS |
CRP (mg/dl) | 5.22 ± 1.13 | 4.28 ± 1.28 | 4.43 ± 1.56 | 3.54 ± 1.25 | 3.38 ± 0.98 | 0.000 |
Hematologic | ||||||
Hemoglobin (g/L) | 147.4 ± 16.2 | 147.5 ± 15.3 | 146.2 ± 15.6 | 146.8 ± 16.0 | 147.6 ± 15.0 | NS |
Red cell count (10*12/L) | 5.90 ± 1.89 | 5.91 ± 1.92 | 6.00 ± 1.91 | 6.15 ± 1.94 | 6.09 ± 1.99 | 0.017 |
White cell count (10*9/L) | 9.20 ± 3.69 | 8.57 ± 2.99 | 8.41 ± 3.08 | 8.59 ± 3.34 | 8.74 ± 3.36 | 0.005 |
Platelet count | 230.9 ± 72.7 | 228.8 ± 5.96 | 225.6 ± 58.8 | 233.8 ± 58.2 | 236.1 ± 64.2 | NS |
RDW (%) | 12.96 ± 0.69 | 13.03 ± 0.62 | 12.80 ± 0.71 | 12.71 ± 0.79 | 12.91 ± 1.28 | 0.018 |
Echocardiography | ||||||
LVDd (mm) | 50.28 ± 5.38 | 49.64 ± 5.27 | 49.87 ± 5.84 | 49.92 ± 5.71 | 49.42 ± 5.44 | 0.028 |
IVST (mm) | 10.07 ± 1.53 | 10.21 ± 1.51 | 10.13 ± 1.59 | 10.32 ± 1.58 | 10.05 ± 1.60 | 0.002 |
EF (%) | 59.3 ± 9.2 | 59.8 ± 8.9 | 59.8 ± 9.5 | 59.8 ± 9.1 | 59.8 ± 9.0 | NS |