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Table 2 Biochemical parameters and echocardiogram findings

From: Trend in young coronary artery disease in China from 2010 to 2014: a retrospective study of young patients ≤ 45

Variable

2010

(n = 804)

2011

(n = 930)

2012

(n = 1045)

2013

(n = 1241)

2014

(n = 1268)

P

Biochemical

      

 TC (mmol/L)

4.54 ± 1.26

4.48 ± 1.16

4.44 ± 1.35

4.42 ± 1.19

4.35 ± 1.26

0.020

 TG (mmol/L)

3.12 ± 6.26

2.23 ± 1.51

2.28 ± 1.88

2.31 ± 1.89

2.49 ± 6.83

0.026

 LDL (mmol/L)

3.21 ± 8.39

2.26 ± 0.96

2.75 ± 1.09

2.74 ± 1.01

2.77 ± 3.26

NS

 HDL (mmol/L)

0.99 ± 0.22

0.94 ± 0.23

0.91 ± 0.21

0.89 ± 0.21

0.89 ± 0.20

0.000

 Creatinine (mg/dL)

82.59 ± 34.06

78.41 ± 16.91

78.83 ± 47.32

77.85 ± 45.99

77.79 ± 18.38

0.030

 BUN (mmol/L)

7.61 ± 4.85

7.29 ± 4.55

7.66 ± 5.17

7.51 ± 4.54

7.18 ± 4.53

NS

 UA (μmol/L)

372.1 ± 111.2

355.5 ± 88.9

359.9 ± 91.3

367.9 ± 93.4

380.4 ± 91.9

0.000

 ALT (U/L)

50.2 ± 48.3

45.4 ± 35.2

48.6 ± 43.1

46.8 ± 41.4

48.1 ± 42.0

NS

 AST (U/L)

62.3 ± 92.7

56.7 ± 89.5

52.2 ± 77.2

51.2 ± 74.3

53.1 ± 77.4

NS

 CK (U/L)

386.9 ± 875.3

368.3 ± 894.6

314.4 ± 737.5

336.8 ± 718.7

377.7 ± 928.1

NS

 CKMB (ng/ml)

33.7 ± 76.1

29.4 ± 82.1

20.8 ± 60.5

26.0 ± 138.1

29.5 ± 141.3

NS

 cTnT (ng/ml)

1.94 ± 1.43

1.82 ± 1.31

1.87 ± 1.53

1.97 ± 2.23

1.95 ± 1.97

NS

 NT-proBNP (pg/ml)

657.0 ± 3973.8

385.6 ± 1348.7

372.8 ± 1638.5

206.8 ± 572.4

197.0 ± 561.7

0.000

 Glucose (mmol/L)

6.73 ± 2.89

6.45 ± 2.51

6.57 ± 2.71

6.67 ± 2.68

6.56 ± 2.88

NS

 HbA1c (%)

6.86 ± 1.76

6.64 ± 1.72

6.71 ± 1.71

6.16 ± 1.70

6.36 ± 1.63

NS

 CRP (mg/dl)

5.22 ± 1.13

4.28 ± 1.28

4.43 ± 1.56

3.54 ± 1.25

3.38 ± 0.98

0.000

Hematologic

      

 Hemoglobin (g/L)

147.4 ± 16.2

147.5 ± 15.3

146.2 ± 15.6

146.8 ± 16.0

147.6 ± 15.0

NS

 Red cell count (10*12/L)

5.90 ± 1.89

5.91 ± 1.92

6.00 ± 1.91

6.15 ± 1.94

6.09 ± 1.99

0.017

 White cell count (10*9/L)

9.20 ± 3.69

8.57 ± 2.99

8.41 ± 3.08

8.59 ± 3.34

8.74 ± 3.36

0.005

 Platelet count

230.9 ± 72.7

228.8 ± 5.96

225.6 ± 58.8

233.8 ± 58.2

236.1 ± 64.2

NS

 RDW (%)

12.96 ± 0.69

13.03 ± 0.62

12.80 ± 0.71

12.71 ± 0.79

12.91 ± 1.28

0.018

Echocardiography

      

 LVDd (mm)

50.28 ± 5.38

49.64 ± 5.27

49.87 ± 5.84

49.92 ± 5.71

49.42 ± 5.44

0.028

 IVST (mm)

10.07 ± 1.53

10.21 ± 1.51

10.13 ± 1.59

10.32 ± 1.58

10.05 ± 1.60

0.002

 EF (%)

59.3 ± 9.2

59.8 ± 8.9

59.8 ± 9.5

59.8 ± 9.1

59.8 ± 9.0

NS

  1. Abbreviations: TC total cholesterol, TG triglyeride, LDL low density lipoprotein cholesterol, HDL high density lipoprotein cholesterol, Cr creatinine, BUN blood urea nitrogen, UA uric acid, ALT alanine aminotransferase, AST Aspartate transaminase, CK creatine kinase, CKMB creatine kinase MB isoenzyme, cTnT cardiac Troponin T, NT-proBNP N-terminal pro-B-type natriuretic peptide, HbA1c hemoglobin A1c, LVDd left ventricular end-diastolic dimension, IVST interventricular septal thickness, EF ejection fraction