Leg edema with (S)-amlodipine vs conventional amlodipine given in triple therapy for hypertension: a randomized double blind controlled clinical trial

Table 4 Evaluation of mean blood pressure at baseline and after therapy (PP analysis; N = 146)

Variable	Test group		Reference group		p *
Variable	N	mm of Hg (mean ± SD)	N	mm of Hg (mean ± SD)
Baseline (day 0), V1	70	113.01 ± 25.93	76	113.99 ± 12.17	ns
After 30 days of therapy, V2	70	101.08 ± 17.92	76	95.33 ± 12.34	ns
After 60 days of therapy, V3	70	90.08 ± 06.01	76	89.81 ± 8.02	ns
After 90 days of therapy, V4	70	102.50 ± 14.34	76	99.01 ± 08.45	ns
After 120 days of therapy, V5	70	94.42 ± 17.25	76	95.89 ± 03.34	ns
p**		<0.0001		<0.0001

PP per protocol, N number of patients, SD standard deviation, ns not significant
Paired t test was applied; *p value, when compared between the groups; **p value, when V5 value compared with baseline value in same group; p <0.05 = statistically significant

ISSN: 1471-2261