| All patients (n = 1733) | High DHA/AA ≥0.903 (n = 867) | Low DHA/AA <0.903 (n = 866) | P-value |
---|---|---|---|---|
Age (years) | 64.5 ± 11.3 | 67.1 ± 9.2 | 61.8 ± 12.5 | <0.01a |
Male | 77.8Â % | 79.4Â % | 76.2Â % | 0.11 |
Body mass index (kg/m2) | 24.4 ± 3.5 | 24.4 ± 3.1 | 24.4 ± 3.8 | 0.97 |
Hypertension | 73.1Â % | 75.7Â % | 70.6Â % | 0.01a |
Diabetes mellitus | 39.2Â % | 39.8Â % | 38.7Â % | 0.63 |
Dyslipidemia | 70.4Â % | 70.6Â % | 70.2Â % | 0.86 |
Family history of ischemic heart disease | 18.5Â % | 19.1Â % | 17.9Â % | 0.50 |
Smoking | 45.1Â % | 47.6Â % | 42.5Â % | 0.03a |
History of coronary revascularization (PCI or CABG) | 27.7Â % | 26.8Â % | 28.6Â % | 0.38 |
Total cholesterol (mg/dl) | 190.7 ± 35.8 | 190.7 ± 34.2 | 190.7 ± 37.4 | 0.98 |
Triglycerides (mg/dl) | 146.8 ± 95.5 | 155.4 ± 100.2 | 138.4 ± 90.1 | <0.01a |
Low-density lipoprotein cholesterol (mg/dl) | 111.2 ± 30.8 | 111.1 ± 29.9 | 111.2 ± 31.8 | 0.94 |
High-density lipoprotein cholesterol (mg/dl) | 51.7 ± 16.5 | 50.0 ± 15.1 | 53.4 ± 17.6 | <0.01a |
Hemoglobin A1c (%) | 6.3 ± 1.1 | 6.2 ± 0.9 | 6.3 ± 1.2 | 0.44 |
Serum creatinine (mg/dl) | 0.88 ± 0.29 | 0.88 ± 0.27 | 0.87 ± 0.31 | 0.41 |
Estimated glomerular filtration rate (ml/min/1.73 m2) | 68.7 ± 17.7 | 67.0 ± 16.4 | 70.2 ± 18.7 | <0.01a |
EPA (μg/dl) | 73.9 ± 44.0 | 93.5 ± 47.9 | 54.2 ± 28.5 | <0.01a |
EPA/AA | Â | Â | Â | <0.01a |
 Mean | 0.49 ± 0.30 | 0.66 ± 0.32 | 0.32 ± 0.17 |  |
 Median | 0.425 | 0.588 | 0.290 |  |
DHA (μg/dl) | 143.4 ± 52.8 | 170.9 ± 53.0 | 115.9 ± 35.3 | <0.01a |
DHA/AA | Â | Â | Â | <0.01a |
 Mean | 0.95 ± 0.38 | 1.22 ± 0.36 | 0.68 ± 0.15 |  |
 Median | 0.903 | 1.143 | 0.706 |  |
DGLA (μg/dl) | 33.2 ± 12.3 | 30.8 ± 11.5 | 35.6 ± 12.6 | <0.01a |
AA (μg/dl) | 157.4 ± 49.5 | 142.1 ± 33.8 | 172.8 ± 57.4 | <0.01a |
Statins | 53.1Â % | 48.7Â % | 57.5Â % | <0.01a |
Antiplatelet agents | 62.7Â % | 67.5Â % | 58.0Â % | <0.01a |
Renin angiotensin system inhibitor (ACE-I and ARB) | 50.7Â % | 50.1Â % | 51.4Â % | 0.59 |
Calcium channel blockers | 45.6Â % | 47.8Â % | 43.5Â % | 0.08 |
Beta blockers | 38.6Â % | 39.6Â % | 37.6Â % | 0.43 |
Hypoglycemic agents | 21.1Â % | 21.0Â % | 21.1Â % | 0.95 |