Table 3 Hazard ratios of determinants associated with VKA discontinuation in NVAF
Factors | % | Crude HR | Adjusted HR (95 % CI) |
|---|---|---|---|
Size, n | 63,675 | ||
Age | |||
18-29 | 0.07 | 1.60 | 1.65 (1.19 - 2.29) |
30-39 | 0.19 | 1.47 | 1.48 (1.19 - 1.84) |
40-49 | 0.89 | 1.00 | 1.00 (Reference) |
50-59 | 3.59 | 0.88 | 0.88 (0.79 - 0.98) |
60-69 | 16.79 | 0.83 | 0.83 (0.76 - 0.92) |
70-74 | 19.82 | 0.82 | 0.82 (0.75 - 0.91) |
75-79 | 23.78 | 0.78 | 0.79 (0.72 - 0.87) |
80-84 | 19.80 | 0.74 | 0.75 (0.68 - 0.83) |
85-89 | 11.10 | 0.77 | 0.79 (0.71 - 0.87) |
≥90 | 3.97 | 0.77 | 0.80 (0.71 - 0.88) |
Time to treatment initiation | |||
0 day | 39.51 | 1.00 | 1.00 (Reference) |
1-7 days | 23.73 | 1.07 | 1.11 (1.08 - 1.13) |
8-30 days | 12.11 | 1.00 | 1.04 (1.01 - 1.07) |
31-90 days | 5.99 | 1.02 | 1.04 (0.99 - 1.08) |
>90 days | 18.66 | 1.14 | 1.13 (1.10 - 1.17) |
Male | 48.46 | 1.08 | 1.03 (1.01 - 1.05) |
Comorbidities | |||
Hypertension | 64.50 | 0.98 | 0.98 (0.96 - 1.01) |
Myocardial infarction | 19.73 | 1.13 | 1.08 (1.05 - 1.11) |
Angina pectoris | 19.79 | 1.10 | 1.06 (1.04 - 1.09) |
Congestive heart failure | 21.15 | 1.06 | 1.02 (0.99 - 1.05) |
Prior stroke or TIA | 9.36 | 0.90 | 0.90 (0.87 - 0.93) |
Prior bleeding events | |||
Intracranial bleeding | 0.64 | 1.05 | 1.04 (0.92 - 1.18) |
Gastrointestinal bleeding | 4.44 | 1.13 | 1.06 (1.01 - 1.11) |
Other bleeding | 7.83 | 1.04 | 1.01 (0.97 - 1.04) |
Diabetes | 26.00 | 1.03 | 1.01 (0.99 - 1.04) |
Hyperlipidemia | 44.96 | 1.03 | 1.08 (1.03 - 1.13) |
Vascular disease | 11.52 | 1.10 | 1.06 (1.02 - 1.09) |
Chronic renal failure | 9.40 | 1.19 | 1.14 (1.10 - 1.18) |
Complications of alcohol abuse | 2.38 | 1.19 | 1.10 (1.03 - 1.17) |
Liver disease | 1.85 | 1.20 | 1.09 (1.02 - 1.17) |
Cancer | 16.72 | 1.14 | 1.13 (1.10 - 1.16) |
Coagulation defects | 1.42 | 1.16 | 1.08 (0.99 - 1.17) |
Predisposition to falls | 12.46 | 1.03 | 1.01 (0.98 - 1.04) |
Dementia/schizophrenia | 4.97 | 1.04 | 1.04 (0.99 - 1.09) |
Venous thromboembolism | 6.36 | 1.20 | 1.16 (1.12 - 1.21) |
COPD | 25.52 | 1.07 | 1.03 (1.01 - 1.06) |
Medications | |||
ACE | 38.49 | 0.99 | 0.97 (0.95 - 1.00) |
ARB | 23.56 | 0.99 | 1.00 (0.97 - 1.02) |
CCB | 45.28 | 0.99 | 0.98 (0.96 - 1.01) |
Diuretics | 53.37 | 0.99 | 1.00 (0.98 - 1.02) |
Antidepressants | 17.18 | 1.03 | 1.02 (0.99 - 1.04) |
Antipsychotics | 3.64 | 1.07 | 1.03 (0.97 - 1.08) |
NSAIDs | 37.56 | 1.02 | 1.01 (0.99 - 1.03) |
Statins | 40.93 | 1.02 | 0.92 (0.88 - 0.97) |