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Table 3 Hazard ratios of determinants associated with VKA discontinuation in NVAF

From: Long-term vitamin K antagonists treatment patterns of Non-Valvular Atrial Fibrillation (NVAF): a population-based cohort study

Factors % Crude HR Adjusted HR (95 % CI)
Size, n 63,675   
Age
18-29 0.07 1.60 1.65 (1.19 - 2.29)
30-39 0.19 1.47 1.48 (1.19 - 1.84)
40-49 0.89 1.00 1.00 (Reference)
50-59 3.59 0.88 0.88 (0.79 - 0.98)
60-69 16.79 0.83 0.83 (0.76 - 0.92)
70-74 19.82 0.82 0.82 (0.75 - 0.91)
75-79 23.78 0.78 0.79 (0.72 - 0.87)
80-84 19.80 0.74 0.75 (0.68 - 0.83)
85-89 11.10 0.77 0.79 (0.71 - 0.87)
≥90 3.97 0.77 0.80 (0.71 - 0.88)
Time to treatment initiation
0 day 39.51 1.00 1.00 (Reference)
1-7 days 23.73 1.07 1.11 (1.08 - 1.13)
8-30 days 12.11 1.00 1.04 (1.01 - 1.07)
31-90 days 5.99 1.02 1.04 (0.99 - 1.08)
>90 days 18.66 1.14 1.13 (1.10 - 1.17)
Male 48.46 1.08 1.03 (1.01 - 1.05)
Comorbidities
Hypertension 64.50 0.98 0.98 (0.96 - 1.01)
Myocardial infarction 19.73 1.13 1.08 (1.05 - 1.11)
Angina pectoris 19.79 1.10 1.06 (1.04 - 1.09)
Congestive heart failure 21.15 1.06 1.02 (0.99 - 1.05)
Prior stroke or TIA 9.36 0.90 0.90 (0.87 - 0.93)
Prior bleeding events
Intracranial bleeding 0.64 1.05 1.04 (0.92 - 1.18)
Gastrointestinal bleeding 4.44 1.13 1.06 (1.01 - 1.11)
Other bleeding 7.83 1.04 1.01 (0.97 - 1.04)
Diabetes 26.00 1.03 1.01 (0.99 - 1.04)
Hyperlipidemia 44.96 1.03 1.08 (1.03 - 1.13)
Vascular disease 11.52 1.10 1.06 (1.02 - 1.09)
Chronic renal failure 9.40 1.19 1.14 (1.10 - 1.18)
Complications of alcohol abuse 2.38 1.19 1.10 (1.03 - 1.17)
Liver disease 1.85 1.20 1.09 (1.02 - 1.17)
Cancer 16.72 1.14 1.13 (1.10 - 1.16)
Coagulation defects 1.42 1.16 1.08 (0.99 - 1.17)
Predisposition to falls 12.46 1.03 1.01 (0.98 - 1.04)
Dementia/schizophrenia 4.97 1.04 1.04 (0.99 - 1.09)
Venous thromboembolism 6.36 1.20 1.16 (1.12 - 1.21)
COPD 25.52 1.07 1.03 (1.01 - 1.06)
Medications
ACE 38.49 0.99 0.97 (0.95 - 1.00)
ARB 23.56 0.99 1.00 (0.97 - 1.02)
CCB 45.28 0.99 0.98 (0.96 - 1.01)
Diuretics 53.37 0.99 1.00 (0.98 - 1.02)
Antidepressants 17.18 1.03 1.02 (0.99 - 1.04)
Antipsychotics 3.64 1.07 1.03 (0.97 - 1.08)
NSAIDs 37.56 1.02 1.01 (0.99 - 1.03)
Statins 40.93 1.02 0.92 (0.88 - 0.97)
  1. Abbreviations: HR hazard ratio, TIA transient ischemic attack, COPD chronic obstructive pulmonary disease, ACE angiotensin-converting enzyme inhibitors, ARB angiotensin receptor blockers, NSAIDs non-steroidal anti-inflammatory drugs