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Table 3 Short Form-36 (SF-36) for conventionally treated (CTR) and patients whose treatment was guided by BNP and for responders and non-responders at study start and at study end. Responder defined as a patient with a BNP under 300 ng/l and/or a decrease in BNP of at least 40 percent in week 16 of follow-up, compared to study start

From: Can BNP-guided therapy improve health-related quality of life, and do responders to BNP-guided heart failure treatment have improved health-related quality of life? Results from the UPSTEP study

  Study start Study end Study start Study end
  Mean (SD) Mean (SD) Mean (SD) Mean (SD)
  CTR group BNP group p CTR group BNP group p Responders Non-responders p Responders Non-responders p
  n = 127 n = 131 n = 98 n = 100 n = 78 n = 53 n = 68 n = 32
SF-36
PF 46.4 (±27) 45.3 (±26) 0.80 54.8 (±26) 55.2 (±27) 0.78 51.3 (±25) 36.5 (±24) 0.001 52.7 (±26) 42.3 (±23) 0.055
RP 19.1 (±33) 28.4 (±38) 0.06 39.8 (±44) 46.4 (±44) 0.21 32.4 (±38) 22.6 (±37) 0.15 33.5 (±44) 22.7 (±38) 0.20
BP 56.4 (±31) 60.6 (±29) 0.26 65.8 (±29) 69.6 (±29) 0.39 62.7 (±29) 57.4 (±29) 0.32 64.6 (±29) 64.2 (±30) 0.95
GH 47.1 (±20) 48.5 (±18) 0.45 50.9 (±20) 53.8 (±19) 0.51 51.8 (±18) 43.8 (±17) 0.01 52.2 (±20) 45.5 (±17) 0.07
VT 43.1 (±22) 42.0 (±21) 0.61 50.2 (±25) 51.9 (±22) 0.63 43.3 (±22) 40.2 (±19) 0.40 42.5 (±25) 43.0 (±18) 0.91
SF 62.4 (±25) 67.8 (±25) 0.10 75.1 (±24) 73.8 (±25) 0.60 72.6 (±25) 60.5 (±23) 0.006 72.6 (±24) 62.5 (±22) 0.056
RE 41.1 (±45) 49.0 (±45) 0.19 54.5 (±44) 57.1 (±42) 0.75 52.8 (±44) 43.4 (±45) 0.24 55.7 (±44) 44.8 (±45) 0.26
MH 70.0 (±20) 69.6 (±19) 0.82 74.1 (±19) 76 (±17) 0.61 70.1 (±18) 68.8 (±20) 0.69 70.1 (±19) 69.5 (±19) 0.87
PCS 31.5 (±11) 32.7 (±11) 0.24 35.6 (±11) 37.8 (±12) 0.18 34.9 (±10) 29.6 (±11) 0.007 35.5 (±11) 31.6 (±11) 0.09
MCS 42.7 (±12) 43.6 (±11) 0.60 46.0 (±11) 46.5 (±10) 0.87 44.3 (±11) 42.7 (±11) 0.45 44.3 (±11) 43.1 (±11) 0.63
  1. Abbreviations: PF Physical functioning, RP Role limitations due to physical health problems, BP Bodily pain, GH General health, VT Vitality, SF Social functioning, RE Role limitations due to emotional health problems, MH Mental health, PCS Physical component score, MCS Mental component score, SD Standard Deviation