Table 1 Baseline characteristics for conventionally treated (CTR group) and patients whose treatment was guided by BNP (BNP group) and for non-responders and responders (defined as a patient with a BNP < 300 ng/l and/or a decrease in BNP of at least 40 % in week 16 compared to BNP at study start) (ref art 2)
Characteristics | BNP group | CTR group | p-value | Responders | Non-responders | p-value |
|---|---|---|---|---|---|---|
n = 147 | n = 132 | n = 78 | n = 53 | |||
Background | ||||||
Age years (SD) | 71.6 (±9.7) | 70.1 (±10) | 0.19 | 69.6 (±10.2) | 74.0 (±8.1) | 0.009 |
Gender male, n (%) | 107 (73 %) | 96 (73 %) | 0.99 | 63 (81 %) | 34 (64 %) | 0.33 |
IHD n (%) | 81 (55 %) | 76 (58 %) | 0.68 | 43 (55 %) | 30 (57 %) | 0.87 |
Hypertension n (%) | 39 (27 %) | 30 (23 %) | 0.46 | 35 (45 %) | 25 (47 %) | 0.80 |
Diabetes Mellitus n (%) | 39 (27 %) | 48 (36 %) | 0.08 | 19 (24 %) | 13 (25 %) | 0.98 |
Physical examination | ||||||
Heart rate beats/min (SD) | 74 (±18) | 73 (±19) | 0.89 | 78 (±20) | 71 (±15) | 0.93 |
Systolic blood pressure, mm Hg (SD) | 126 (±22) | 122 (±22) | 0.12 | 126 (±23) | 125 (±21) | 0.77 |
Diastolic blood pressure, mm Hg (SD) | 75 (±13) | 74 (±13) | 0.42 | 75 (±13) | 74 (±12) | 0.71 |
NYHA functional classes | ||||||
II n (%) | 47 (32 %) | 36 (27 %) | 0.39 | 28 | 18 | 0.09 |
III n (%) | 76 (52 %) | 78 (59 %) | 0.22 | 42 | 27 | 0.74 |
IV n (%) | 22 (15 %) | 18 (14 %) | 0.75 | 8 | 8 | 0.41 |
Medication | ||||||
ACEi n (%) | 113 (77) | 92 (70) | 0.17 | 65 (83) | 37 (70) | 0.67 |
ARB n (%) | 51 (35) | 46 (35) | 0.98 | 23 (29) | 23 (43) | 0.10 |
BB n (%) | 137 (93) | 125 (95) | 0.60 | 75 (96) | 48 (91) | 0.19 |
MRA n (%) | 81 (55) | 78 (59) | 0.50 | 43 (55) | 28 (55) | 0.80 |
Echocardiography (LVEF) | ||||||
<30 % n | 84 (57 %) | 76 (58 %) | 0.94 | 50 (64 %) | 27 (51 %) | 0.13 |
30-40 % n | 63 (43 %) | 56 (42 %) | 0.94 | 28 (36 %) | 26 (49 %) | 0.13 |
Laboratory results | ||||||
BNP ng/l mean (SD) | 808 (±676) | 899 (±915) | 0.34 | 805 (±704) | 778 (±651) | 0.82 |
eGFR mL/min/1.73 m2 mean (SD) | 61.4 (±20.9) | 60.1 (±20.9) | 0.59 | 66.5 (±21.1) | 56.1 (±19.2) | 0.005 |
Potassium mmol/l mean (SD) | 4.3 (±0.5) | 4.2 (±0.5) | 0.38 | 4.3 (±0.50) | 4.3 (±0.52) | 0.80 |