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Table 2 Multivariable-adjusted blood pressure changes in normotensives according to quartiles and 1-SD increment of sodium concentrations

From: The relationship between sodium concentrations in spot urine and blood pressure increases: a prospective study of Japanese general population: the Circulatory Risk in Communities Study (CIRCS)

 

Sodium concentration quartiles in spot urine

 

1(low)

2

3

4(high)

1-SDa

All subjects (n = 889)

     

Number

220

225

220

224

54 mmol/l

 Changes in systolic blood pressure level (mmHg)

  Age- and sex-adjusted

4.3

4.1

5.2

6.9

1.0*

  Multivariable-adjustedb

4.5

4.2

5.1

6.8

0.9

  Multivariable-adjustedc

4.6

4.1

5.2

6.6

0.8

 Changes in diastolic blood pressure level (mmHg)

  Age- and sex-adjusted

0.9

0.6

0.3

2.1

0.4

  Multivariable-adjustedb

1.0

0.7

0.3

2.1

0.4

  Multivariable-adjustedd

0.9

0.4

0.7

1.9

0.4

Non-overweight subjects (BMI < 25) (n = 700)

     

Number

175

174

176

175

53 mmol/l

 Changes in systolic blood pressure level (mmHg)

     

  Age- and sex-adjusted

3.8

4.2

4.2

7.3*

1.1*

  Multivariable-adjustedb

3.9

4.3

4.1

7.3*

1.1*

  Multivariable-adjustedc

4.2

4.1

4.2

7.0*

0.9

 Changes in diastolic blood pressure level (mmHg)

  Age- and sex-adjusted

0.8

0.5

0.1

2.3

0.4

  Multivariable-adjustedb

0.8

0.5

0.0

2.3

0.4

  Multivariable-adjustedd

0.8

0.4

0.3

2.0

0.3

Overweight subjects (BMI ≥ 25) (n = 189)

     

Number

46

48

48

47

55 mmol/l

 Changes in systolic blood pressure level (mmHg)

  Age- and sex-adjusted

5.9

5.0

7.1

6.3

0.2

  Multivariable-adjustedb

5.6

5.0

7.0

6.7

0.4

  Multivariable-adjustedc

5.3

5.0

7.3

6.8

0.6

 Changes in diastolic blood pressure level (mmHg)

     

  Age- and sex-adjusted

2.5

−0.3

0.5

2.9

0.6

  Multivariable-adjustedb

2.4

−0.4

0.6

3.0

0.7

  Multivariable-adjustedd

1.4

−0.1

1.4

2.9

0.9

  1. Difference from the lowest quartile: *P < 0.05
  2. a1-SD corresponed to 54 mol/L for all subjects, 53 mol/L for non-overweight subjects and 55 mmol/L for overweight subjects
  3. bAdjusted for age (years), sex, body mass index (kg/m2), drinking status (never, ex-drinkers, current drinkers of ethanol at 1 to 22 g/day and ≥23 g/day), current smoking (yes or no) and baseline eGFR value (ml/min/1.73 m2)
  4. cAdjustment further for baseline systolic blood pressure levels (mmHg)
  5. dAdjustment further for baseline diastolic blood pressure levels (mmHg)