Controls | Cases | |||||||
---|---|---|---|---|---|---|---|---|
Variables | N | (%) | N | (%) | Crude OR | (95 % CI) | P | |
Sample size | 10,726 | (100.0) | 2,686 | (100.0) | ||||
Female | 3,280 | (30.6) | 824 | (30.7) | ||||
Age (y) | Mean (± SD) | 67.1 | (±10.0) | 67.1 | (±10.0) | |||
CHADS2 score | ||||||||
0 | 8,830 | (82.3) | 1,703 | (63.4) | 1.00 | (Ref.) | ||
1–2 | 1,695 | (15.8) | 838 | (31.2) | 3.33 | (2.99–3.71) | <0.001 | |
> 2 | 201 | (1.9) | 145 | (5.4) | 5.85 | (5.03–6.79) | <0.001 | |
Comorbidities, yes (Ref. = No) | ||||||||
Diabetes mellitus | 800 | (7.5) | 552 | (20.6) | 3.33 | (2.94–3.76) | <0.001 | |
Hypertension | 418 | (3.9) | 268 | (10) | 2.77 | (2.36–3.26) | <0.001 | |
Congestive heart failure | 800 | (7.5) | 570 | (21.2) | 3.43 | (3.04–3.87) | <0.001 | |
Stroke | 1,372 | (12.8) | 654 | (24.3) | 2.21 | (1.98–2.45) | <0.001 | |
Asthma | 133 | (1.2) | 74 | (2.8) | 2.28 | (1.70–3.04) | <0.001 | |
COPD | 246 | (2.3) | 196 | (7.3) | 3.43 | (2.82–4.18) | <0.001 | |
Chronic kidney disease | 118 | (1.1) | 108 | (4) | 3.76 | (2.88–4.91) | <0.001 | |
Chronic liver disease | 28 | (0.3) | 16 | (0.6) | 2.29 | (1.23–4.22) | 0.008 | |
Parkinson disease | 20 | (0.2) | 8 | (0.3) | 1.60 | (0.70–3.63) | 0.260 | |
Dementia | 49 | (0.5) | 24 | (0.9) | 1.96 | (1.20–3.19) | 0.007 | |
Medication use, yes (Ref. = No) | ||||||||
Antineoplastic drug | 67 | (0.6) | 71 | (2.6) | 4.35 | (3.10–6.10) | <0.001 | |
PPI | 1,127 | (10.5) | 665 | (24.8) | 2.86 | (2.56–3.19) | <0.001 | |
Steroid | 1,756 | (16.4) | 736 | (27.4) | 1.96 | (1.77–2.16) | <0.001 | |
ACEI/ARB | 5,983 | (55.8) | 1,674 | (62.3) | 1.33 | (1.21–1.45) | <0.001 | |
Antiviral drug | 143 | (1.3) | 47 | (1.7) | 1.32 | (0.95–1.84) | 0.100 | |
Immunosuppressants | 19 | (0.2) | 12 | (0.4) | 2.53 | (1.22–5.20) | 0.010 | |
Immuostimulants | 7 | (0.1) | 8 | (0.3) | 5.01 | (1.72–14.5) | 0.003 | |
Nitrate | 6,277 | (58.5) | 1,847 | (68.8) | 1.62 | (1.47–1.78) | <0.001 | |
Antiplatelet | 9,151 | (85.3) | 2,330 | (86.7) | 1.13 | (0.99–1.28) | 0.050 | |
Vaccine (influenza or pneumococcal) | 2,551 | (23.8) | 631 | (22.8) | 0.94 | (0.85–1.05) | 0.280 |