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Table 7 12-month Pre-index demographic and clinical characteristics for hyperlipidemic patients with and without new CV events before matching

From: Clinical and economic burden associated with cardiovascular events among patients with hyperlipidemia: a retrospective cohort study

  History of CV event cohort Modified CHD RE cohort Moderate risk cohort Low risk cohort
  Without CV events With CV events   Without CV events With CV events   Without CV events With CV events   Without CV events With CV events  
(N = 10744) (N = 77163) (N = 145642) (N = 156793) (N = 11816 (N = 14544) (N = 16083) (N = 18665)
Mean [%]/(SD) Mean [%]/(SD) P-valuea STD Mean [%]/(SD) Mean [%]/(SD) P-valuea STD Mean [%]/(SD) Mean [%]/(SD) P-valuea STD Mean [%]/(SD) Mean [%]/(SD) P-valuea STD
Age 73.66 (13.15) 66.41 (13.65) <0.0001   65.28 (13.16) 65.17 (13.17) 0.0189   67.83 (12.63) 65.83 (12.83) <0.0001   57.73 (12.45) 54.56 (11.01) <0.0001  
18-24 [0.0 %] [0.0 %] 0.04 2.8 [0.03 %] [0.05 %] 0.0018 1.1 [0.00 %] [0.00 %] N/A 0.0 [0.2 %] [0.2 %] 0.3062 1.1
25-34 [0.1 %] [0.4 %] <0.0001 6.6 [0.3 %] [0.4 %] 0.0002 1.4 [0.00 %] [0.00 %] N/A 0.0 [1.3 %] [1.8 %] 0.0016 3.4
35-54 [6.9 %] [18.4 %] <0.0001 34.8 [19.6 %] [19.6 %] 0.6784 0.2 [11.7 %] [16.7 %] <0.0001 14.3 [41.3 %] [51.1 %] <0.0001 19.8
55-64 [22.1 %] [32.1 %] <0.0001 22.7 [35.7 %] [35.3 %] 0.0122 0.9 [38.0 %] [41.2 %] <0.0001 6.6 [34.7 %] [33.6 %] 0.0327 2.3
≥65 [70.9 %] [49.2 %] <0.0001 45.6 [44.4 %] [44.7 %] 0.1341 0.5 [50.3 %] [42.1 %] <0.0001 16.5 [22.5 %] [13.3 %] <0.0001 24.1
Male [66.6 %] [63.0 %] <00001 7.7 [62.2 %] [61.1 %] <0.0001 2.4 [62.4 %] [65.2 %] <0.0001 5.9 [60.2 %] [66.4 %] <0.0001 0.1
US geographic region                 
Northeast [39.3 %] [36.0 %] <0.0001 6.8 [35.3 %] [34.9 %] 0.0398 0.7 [33.1 %] [31.0 %] 0.0003 4.5 [35.8 %] [31.4 %] <0.0001 9.4
Midwest [22.1 %] [25.5 %] <0.0001 8.0 [26.2 %] [26.2 %] 0.2635 0.4 [27.2 %] [28.2 %] 0.0671 2.3 [25.0 %] [28.4 %] <0.0001 7.6
South [24.4 %] [26.3 %] <0.0001 4.4 [26.8 %] [27.3 %] 0.0006 1.3 [26.0 %] [28.3 %] <0.0001 5.2 [27.8 %] [30.4 %] <0.0001 5.7
West [14.2 %] [12.2 %] <0.0001 5.9 [11.5 %] [11.5 %] 0.864 0.1 [13.7 %] [12.5 %] 0.004 3.6 [11.3 %] [9.8 %] <0.0001 5.0
Baseline comorbid condition                 
Charlson comorbidity index (CCI) 2.72(2.15) 3.30(2.65) <0.0001 24.3 0.99(1.49) 2.10(2.27) <0.0001 57.6 0.53 (1.23) 0.92(1.69) <0.0001 26.6 0.22(0.78) 0.33 (1.05) <0.0001 11.4
Chronic disease score 5.28(4.06) 6.01(4.44) <0.0001 17.0 3.91(3.48) 5.70(4.24) <0.0001 46.2 4.17 (3.04) 4.70(3.40) <0.0001 16.6 1.16(1.94) 1.28 (2.22) <0.0001 5.8
Baseline number of inpatient visits PPPM 0.19(0.49) 0.39(0.84) <0.0001 28.8 0.04(0.19) 0.18(0.52) <0.0001 36.1 0.03 (0.19) 0.10(0.35) <0.0001 24.3 0.01 (0.07) 0.03 (0.20) <0.0001 15.6
  1. CHD RE coronary heart disease risk equivalent, SD standard deviation, STD standardized difference, CV cardiovascular, CVD cardiovascular disease, PPPM per patient per month
  2. aChi-square tests were used to evaluate the statistical significance of differences in categorical variables; student t-tests were used for the continuous variables