Fig. 2

Pharmacokinetic model for the intravascular concentration of gadofosveset. Using various dual injection techniques, a fixed percentage of the total volume is injected as the bolus phase, followed by remainder as a slow infusion over a targeted duration to maintain a steady state concentration. A 100 % bolus is also plotted for reference. The 2-compartment model assumes immediate injection and arterial-venous mixing (equilibrium)