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Table 3 Distribution of polymorphism genotypes in groups with and without ISR, minor alele frequencies (MAF) and logistic regression analysis, separately for each parameter with adjustment for diabetes mellitus

From: The rs1803274 polymorphism of the BCHE gene is associated with an increased risk of coronary in-stent restenosis

Gene, polymorphism Distribution of polymorphism genotypes MAF in general CZ population, ISR and non-ISR groups; statistics Logistic regression analysis, compared to the wild type allele with adjustment for diabetes mellitus
  ISR group Non-ISR group p Czech GP ISR vs. GP Non-ISR vs GP OR 95 % CI for OR p
No of pts (%) No of pts (%) p p
BCHE, rs1803274          0.016
 No of pts (n) 160 158        
 GG 102 (63.8 %) 122 (77.2 %)        
 GA 50 (31.2 %) 35 (22.2 %)      1.715 1.034 - 2.846 0.037
 AA 8 (5 %) 1 (0.6 %) 0.008 a     9.703 a 1.191 - 79.05 a 0.034 a
 GA + AA 58 (36.2 %) 36 (22.8 %) 0.009     1.934 1.181 -3.166 0.009
 MAF 0.21 0.12 0.007 0.18 0.280 0.367    
ROS1, rs529038          0.280
 No of pts (n) 160 160        
 GG 75 (46.9 %) 78 (48.8 %)        
 GA 75 (46.9 %) 65 (40.6 %)      1.200 0.758 - 1.899 0.436
 AA 10 (6.2 %) 17 (10.6 %) 0.269     0.612 0.263 - 1.421 0.253
 GA + AA 86 (53.8 %) 82 (51.2 %) 0.823     1.078 0.695 - 1.672 0.737
MAF 0.3 0.31 1 0.3 1 1    
UPC3, rs1800849          0.982
 No of pts (n) 149 160        
 CC 86 (57.8 %) 90 (56.2 %)        
 CT 51 (34.2 %) 63 (39.4 %)      0.847 0.527 - 1.361 0.492
 TT 12 (8.1 %) 7 (4.8 %) 0.323     1.792 0.670 - 4.793 0.245
 CT + TT 63 (42.3 %) 70 (43.8 %) 0.795     0.939 0.597–1.477 0.785
 MAF 0,25 0,24 1 0,28 1 0,696    
GPX1, rs1050450          0.981
 No of pts (n) 157 160        
 CC 72 (46 %) 76 (47.5 %)        
 CT 74 (47.1 %) 71 (44.5 %)      1.085 0.687 - 1.715 0.726
 TT 10 (6.4 %) 13 (8.1 %) 0.788     0.801 0.331 - 1.941 0.623
 CT + TT 84 (53.5 %) 84 (52.5 %) 0.811     1.041 0.670 - 1.619 0.857
 MAF 0.3 0.3 1 0.23 0.101 0.094    
ALOX5AP, rs17216473          1.000
 No of pts (n) 149 160        
 GG 113 (75.8 %) 120 (75 %)        
 GA 36 (24.2 %) 38 (23.8 %)      1.007 0.597 - 1.699 0.980
 AA 0 2 (1.2 %) 0.642     - - 0.999
 GA + AA 36 (24.2 %) 40 (25 %) 0.895     0.956 0.569 - 1.605 0.865
 MAF 0.12 0.13 1 0.09 0.738 1    
APOE, rs7412, rs429358          0.995
 No of pts (n) 154 160        
 *2/*2 1 (0.6 %) 0      - - 1.000
 2.3 12 (7.8 %) 15 (9.4 %)      0.814 0.363 - 1.826 0.618
 2.4 2 (1.3 %) 2 (1.2 %)      1.019 0.141 - 7.369 0.985
 *2/*2; *2/*3; *2/*4 15 (9.7 %) 17 (10.6 %) 0.975     0.899 0.427 - 1.896 0.781
 3/3 (wild) 106 (68.8 %) 108 (67.5 %) 0.952       
 3.4 31 (20.1 %) 32 (20 %)      0.987 0.563 - 1.732 0.964
 4.4 2 (1.3 %) 3 (1.9 %)      0.680 0.111 - 4.152 0.676
 3/4;4/4 33 (21.4 %) 35 (21.9 %)      0.960 0.556 - 1.658 0.885
 MAF *2 0.05 0.05 1 0.08 0.343 0.383    
 MAF *4 0.11 0.12 1 0.14 0.831 1
GC, rs7041          0.722
No of pts (n) 154 160        
 TT 17 (11 %) 19 (11.9 %)        
 TG 83 (53.9 %) 79 (49.4 %)      1.176 0.570 - 2.424 0.661
 GG 54 (35.1 %) 62 (38.8 %) 0.741     0.974 0.460 - 2.060 0.945
 TG + GG 137 (89 %) 141 (88.1 %) 0.861     1.086 0.542 - 2.178 0.815
 MAF 0.38 0.37 1 0.43 0.374 1    
GC, rs4588          0.803
 No of pts (n) 149 160        
 CC 73 (49 %) 82 (51.2 %)        
 CA 64 (43 %) 68 (42.5 %)      1.059 0.665 - 1.686 0.810
 AA 12 (8.1 %) 10 (6.2 %) 0.821     1.350 0.551 - 3.311 0.512
 CA + AA 76 (51.0 %) 78 (48.8 %) 0.733     1.096 0.701–1.713 0.688
 MAF 0.29 0.28 1 0.31 1 1    
VDR, rs2228570          0.913
 No of pts (n) 149 160        
 TT 30 (20.1 %) 32 (20 %)        
 TC 70 (47 %) 79 (49.4 %)      0.945 0.552 - 1.544 0.760
 CC 49 (32.9 %) 49 (30.6 %) 0.9     1.065 0.169 - 3.577 0.747
 TC + CC 119 (79.9 %) 128 (80 %) 1     0.991 0.553 - 1.498 0.711
 MAF 0.43 0.45 1 0.43 1 1    
LRP1, rs1799986          0.913
No of pts (n) 149 160        
 CC 109 (73.2 %) 114 (71.2 %)        
 CT 37 (24.8 %) 42 (26.2 %)      0.923 0.552 - 1.544 0.760
 TT 3 (2.0 %) 4 (2.5 %) 0.941     0.778 0.169 - 3.577 0.747
 CT + TT 40 (26.8 %) 46 (28.8 %) 0.8     0.910 0.553 - 1.498 0.711
 MAF 0.14 0.15 1 0.16 1 1    
LDLR, rs2228671          0.716
 No of pts (n) 149 160        
 CC 124 (83.2 %) 130 (81.2 %)        
 CT 22 (14.8 %) 28 (17.5 %)      0.824 0.447 - 1.516 0.533
 TT 3 (2 %) 2 (1.2 %) 0.679     1.579 0.259 - 9.617 0.620
 CT + TT 25 (16.9 %) 30 (18.8 %) 0.659     0.874 0.487 - 1.569 0.651
 MAF 0.09 0.1 1 0.1 1 1    
  1. p = chi-square test
  2. GP general population, CZ Czech
  3. athe confidence interval - for rs1803274 homozygotes AA vs. GG is too wide. Therefore the data were analyzed only in the setting of a dominant model