Gene, polymorphism | Distribution of polymorphism genotypes | MAF in general CZ population, ISR and non-ISR groups; statistics | Logistic regression analysis, compared to the wild type allele with adjustment for diabetes mellitus | ||||||
---|---|---|---|---|---|---|---|---|---|
ISR group | Non-ISR group | p | Czech GP | ISR vs. GP | Non-ISR vs GP | OR | 95 % CI for OR | p | |
No of pts (%) | No of pts (%) | p | p | ||||||
BCHE, rs1803274 | 0.016 | ||||||||
No of pts (n) | 160 | 158 | |||||||
GG | 102 (63.8 %) | 122 (77.2 %) | |||||||
GA | 50 (31.2 %) | 35 (22.2 %) | 1.715 | 1.034 - 2.846 | 0.037 | ||||
AA | 8 (5 %) | 1 (0.6 %) | 0.008 a | 9.703 a | 1.191 - 79.05 a | 0.034 a | |||
GA + AA | 58 (36.2 %) | 36 (22.8 %) | 0.009 | 1.934 | 1.181 -3.166 | 0.009 | |||
MAF | 0.21 | 0.12 | 0.007 | 0.18 | 0.280 | 0.367 | |||
ROS1, rs529038 | 0.280 | ||||||||
No of pts (n) | 160 | 160 | |||||||
GG | 75 (46.9 %) | 78 (48.8 %) | |||||||
GA | 75 (46.9 %) | 65 (40.6 %) | 1.200 | 0.758 - 1.899 | 0.436 | ||||
AA | 10 (6.2 %) | 17 (10.6 %) | 0.269 | 0.612 | 0.263 - 1.421 | 0.253 | |||
GA + AA | 86 (53.8 %) | 82 (51.2 %) | 0.823 | 1.078 | 0.695 - 1.672 | 0.737 | |||
MAF | 0.3 | 0.31 | 1 | 0.3 | 1 | 1 | |||
UPC3, rs1800849 | 0.982 | ||||||||
No of pts (n) | 149 | 160 | |||||||
CC | 86 (57.8 %) | 90 (56.2 %) | |||||||
CT | 51 (34.2 %) | 63 (39.4 %) | 0.847 | 0.527 - 1.361 | 0.492 | ||||
TT | 12 (8.1 %) | 7 (4.8 %) | 0.323 | 1.792 | 0.670 - 4.793 | 0.245 | |||
CT + TT | 63 (42.3 %) | 70 (43.8 %) | 0.795 | 0.939 | 0.597–1.477 | 0.785 | |||
MAF | 0,25 | 0,24 | 1 | 0,28 | 1 | 0,696 | |||
GPX1, rs1050450 | 0.981 | ||||||||
No of pts (n) | 157 | 160 | |||||||
CC | 72 (46 %) | 76 (47.5 %) | |||||||
CT | 74 (47.1 %) | 71 (44.5 %) | 1.085 | 0.687 - 1.715 | 0.726 | ||||
TT | 10 (6.4 %) | 13 (8.1 %) | 0.788 | 0.801 | 0.331 - 1.941 | 0.623 | |||
CT + TT | 84 (53.5 %) | 84 (52.5 %) | 0.811 | 1.041 | 0.670 - 1.619 | 0.857 | |||
MAF | 0.3 | 0.3 | 1 | 0.23 | 0.101 | 0.094 | |||
ALOX5AP, rs17216473 | 1.000 | ||||||||
No of pts (n) | 149 | 160 | |||||||
GG | 113 (75.8 %) | 120 (75 %) | |||||||
GA | 36 (24.2 %) | 38 (23.8 %) | 1.007 | 0.597 - 1.699 | 0.980 | ||||
AA | 0 | 2 (1.2 %) | 0.642 | - | - | 0.999 | |||
GA + AA | 36 (24.2 %) | 40 (25 %) | 0.895 | 0.956 | 0.569 - 1.605 | 0.865 | |||
MAF | 0.12 | 0.13 | 1 | 0.09 | 0.738 | 1 | |||
APOE, rs7412, rs429358 | 0.995 | ||||||||
No of pts (n) | 154 | 160 | |||||||
*2/*2 | 1 (0.6 %) | 0 | - | - | 1.000 | ||||
2.3 | 12 (7.8 %) | 15 (9.4 %) | 0.814 | 0.363 - 1.826 | 0.618 | ||||
2.4 | 2 (1.3 %) | 2 (1.2 %) | 1.019 | 0.141 - 7.369 | 0.985 | ||||
*2/*2; *2/*3; *2/*4 | 15 (9.7 %) | 17 (10.6 %) | 0.975 | 0.899 | 0.427 - 1.896 | 0.781 | |||
3/3 (wild) | 106 (68.8 %) | 108 (67.5 %) | 0.952 | ||||||
3.4 | 31 (20.1 %) | 32 (20 %) | 0.987 | 0.563 - 1.732 | 0.964 | ||||
4.4 | 2 (1.3 %) | 3 (1.9 %) | 0.680 | 0.111 - 4.152 | 0.676 | ||||
3/4;4/4 | 33 (21.4 %) | 35 (21.9 %) | 0.960 | 0.556 - 1.658 | 0.885 | ||||
MAF *2 | 0.05 | 0.05 | 1 | 0.08 | 0.343 | 0.383 | |||
MAF *4 | 0.11 | 0.12 | 1 | 0.14 | 0.831 | 1 | |||
GC, rs7041 | 0.722 | ||||||||
No of pts (n) | 154 | 160 | |||||||
TT | 17 (11 %) | 19 (11.9 %) | |||||||
TG | 83 (53.9 %) | 79 (49.4 %) | 1.176 | 0.570 - 2.424 | 0.661 | ||||
GG | 54 (35.1 %) | 62 (38.8 %) | 0.741 | 0.974 | 0.460 - 2.060 | 0.945 | |||
TG + GG | 137 (89 %) | 141 (88.1 %) | 0.861 | 1.086 | 0.542 - 2.178 | 0.815 | |||
MAF | 0.38 | 0.37 | 1 | 0.43 | 0.374 | 1 | |||
GC, rs4588 | 0.803 | ||||||||
No of pts (n) | 149 | 160 | |||||||
CC | 73 (49 %) | 82 (51.2 %) | |||||||
CA | 64 (43 %) | 68 (42.5 %) | 1.059 | 0.665 - 1.686 | 0.810 | ||||
AA | 12 (8.1 %) | 10 (6.2 %) | 0.821 | 1.350 | 0.551 - 3.311 | 0.512 | |||
CA + AA | 76 (51.0 %) | 78 (48.8 %) | 0.733 | 1.096 | 0.701–1.713 | 0.688 | |||
MAF | 0.29 | 0.28 | 1 | 0.31 | 1 | 1 | |||
VDR, rs2228570 | 0.913 | ||||||||
No of pts (n) | 149 | 160 | |||||||
TT | 30 (20.1 %) | 32 (20 %) | |||||||
TC | 70 (47 %) | 79 (49.4 %) | 0.945 | 0.552 - 1.544 | 0.760 | ||||
CC | 49 (32.9 %) | 49 (30.6 %) | 0.9 | 1.065 | 0.169 - 3.577 | 0.747 | |||
TC + CC | 119 (79.9 %) | 128 (80 %) | 1 | 0.991 | 0.553 - 1.498 | 0.711 | |||
MAF | 0.43 | 0.45 | 1 | 0.43 | 1 | 1 | |||
LRP1, rs1799986 | 0.913 | ||||||||
No of pts (n) | 149 | 160 | |||||||
CC | 109 (73.2 %) | 114 (71.2 %) | |||||||
CT | 37 (24.8 %) | 42 (26.2 %) | 0.923 | 0.552 - 1.544 | 0.760 | ||||
TT | 3 (2.0 %) | 4 (2.5 %) | 0.941 | 0.778 | 0.169 - 3.577 | 0.747 | |||
CT + TT | 40 (26.8 %) | 46 (28.8 %) | 0.8 | 0.910 | 0.553 - 1.498 | 0.711 | |||
MAF | 0.14 | 0.15 | 1 | 0.16 | 1 | 1 | |||
LDLR, rs2228671 | 0.716 | ||||||||
No of pts (n) | 149 | 160 | |||||||
CC | 124 (83.2 %) | 130 (81.2 %) | |||||||
CT | 22 (14.8 %) | 28 (17.5 %) | 0.824 | 0.447 - 1.516 | 0.533 | ||||
TT | 3 (2 %) | 2 (1.2 %) | 0.679 | 1.579 | 0.259 - 9.617 | 0.620 | |||
CT + TT | 25 (16.9 %) | 30 (18.8 %) | 0.659 | 0.874 | 0.487 - 1.569 | 0.651 | |||
MAF | 0.09 | 0.1 | 1 | 0.1 | 1 | 1 |