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Table 3 Distribution of polymorphism genotypes in groups with and without ISR, minor alele frequencies (MAF) and logistic regression analysis, separately for each parameter with adjustment for diabetes mellitus

From: The rs1803274 polymorphism of the BCHE gene is associated with an increased risk of coronary in-stent restenosis

Gene, polymorphism

Distribution of polymorphism genotypes

MAF in general CZ population, ISR and non-ISR groups; statistics

Logistic regression analysis, compared to the wild type allele with adjustment for diabetes mellitus

 

ISR group

Non-ISR group

p

Czech GP

ISR vs. GP

Non-ISR vs GP

OR

95 % CI for OR

p

No of pts (%)

No of pts (%)

p

p

BCHE, rs1803274

        

0.016

 No of pts (n)

160

158

       

 GG

102 (63.8 %)

122 (77.2 %)

       

 GA

50 (31.2 %)

35 (22.2 %)

    

1.715

1.034 - 2.846

0.037

 AA

8 (5 %)

1 (0.6 %)

0.008 a

   

9.703 a

1.191 - 79.05 a

0.034 a

 GA + AA

58 (36.2 %)

36 (22.8 %)

0.009

   

1.934

1.181 -3.166

0.009

 MAF

0.21

0.12

0.007

0.18

0.280

0.367

   

ROS1, rs529038

        

0.280

 No of pts (n)

160

160

       

 GG

75 (46.9 %)

78 (48.8 %)

       

 GA

75 (46.9 %)

65 (40.6 %)

    

1.200

0.758 - 1.899

0.436

 AA

10 (6.2 %)

17 (10.6 %)

0.269

   

0.612

0.263 - 1.421

0.253

 GA + AA

86 (53.8 %)

82 (51.2 %)

0.823

   

1.078

0.695 - 1.672

0.737

MAF

0.3

0.31

1

0.3

1

1

   

UPC3, rs1800849

        

0.982

 No of pts (n)

149

160

       

 CC

86 (57.8 %)

90 (56.2 %)

       

 CT

51 (34.2 %)

63 (39.4 %)

    

0.847

0.527 - 1.361

0.492

 TT

12 (8.1 %)

7 (4.8 %)

0.323

   

1.792

0.670 - 4.793

0.245

 CT + TT

63 (42.3 %)

70 (43.8 %)

0.795

   

0.939

0.597–1.477

0.785

 MAF

0,25

0,24

1

0,28

1

0,696

   

GPX1, rs1050450

        

0.981

 No of pts (n)

157

160

       

 CC

72 (46 %)

76 (47.5 %)

       

 CT

74 (47.1 %)

71 (44.5 %)

    

1.085

0.687 - 1.715

0.726

 TT

10 (6.4 %)

13 (8.1 %)

0.788

   

0.801

0.331 - 1.941

0.623

 CT + TT

84 (53.5 %)

84 (52.5 %)

0.811

   

1.041

0.670 - 1.619

0.857

 MAF

0.3

0.3

1

0.23

0.101

0.094

   

ALOX5AP, rs17216473

        

1.000

 No of pts (n)

149

160

       

 GG

113 (75.8 %)

120 (75 %)

       

 GA

36 (24.2 %)

38 (23.8 %)

    

1.007

0.597 - 1.699

0.980

 AA

0

2 (1.2 %)

0.642

   

-

-

0.999

 GA + AA

36 (24.2 %)

40 (25 %)

0.895

   

0.956

0.569 - 1.605

0.865

 MAF

0.12

0.13

1

0.09

0.738

1

   

APOE, rs7412, rs429358

        

0.995

 No of pts (n)

154

160

       

 *2/*2

1 (0.6 %)

0

    

-

-

1.000

 2.3

12 (7.8 %)

15 (9.4 %)

    

0.814

0.363 - 1.826

0.618

 2.4

2 (1.3 %)

2 (1.2 %)

    

1.019

0.141 - 7.369

0.985

 *2/*2; *2/*3; *2/*4

15 (9.7 %)

17 (10.6 %)

0.975

   

0.899

0.427 - 1.896

0.781

 3/3 (wild)

106 (68.8 %)

108 (67.5 %)

0.952

      

 3.4

31 (20.1 %)

32 (20 %)

    

0.987

0.563 - 1.732

0.964

 4.4

2 (1.3 %)

3 (1.9 %)

    

0.680

0.111 - 4.152

0.676

 3/4;4/4

33 (21.4 %)

35 (21.9 %)

    

0.960

0.556 - 1.658

0.885

 MAF *2

0.05

0.05

1

0.08

0.343

0.383

   

 MAF *4

0.11

0.12

1

0.14

0.831

1

GC, rs7041

        

0.722

No of pts (n)

154

160

       

 TT

17 (11 %)

19 (11.9 %)

       

 TG

83 (53.9 %)

79 (49.4 %)

    

1.176

0.570 - 2.424

0.661

 GG

54 (35.1 %)

62 (38.8 %)

0.741

   

0.974

0.460 - 2.060

0.945

 TG + GG

137 (89 %)

141 (88.1 %)

0.861

   

1.086

0.542 - 2.178

0.815

 MAF

0.38

0.37

1

0.43

0.374

1

   

GC, rs4588

        

0.803

 No of pts (n)

149

160

       

 CC

73 (49 %)

82 (51.2 %)

       

 CA

64 (43 %)

68 (42.5 %)

    

1.059

0.665 - 1.686

0.810

 AA

12 (8.1 %)

10 (6.2 %)

0.821

   

1.350

0.551 - 3.311

0.512

 CA + AA

76 (51.0 %)

78 (48.8 %)

0.733

   

1.096

0.701–1.713

0.688

 MAF

0.29

0.28

1

0.31

1

1

   

VDR, rs2228570

        

0.913

 No of pts (n)

149

160

       

 TT

30 (20.1 %)

32 (20 %)

       

 TC

70 (47 %)

79 (49.4 %)

    

0.945

0.552 - 1.544

0.760

 CC

49 (32.9 %)

49 (30.6 %)

0.9

   

1.065

0.169 - 3.577

0.747

 TC + CC

119 (79.9 %)

128 (80 %)

1

   

0.991

0.553 - 1.498

0.711

 MAF

0.43

0.45

1

0.43

1

1

   

LRP1, rs1799986

        

0.913

No of pts (n)

149

160

       

 CC

109 (73.2 %)

114 (71.2 %)

       

 CT

37 (24.8 %)

42 (26.2 %)

    

0.923

0.552 - 1.544

0.760

 TT

3 (2.0 %)

4 (2.5 %)

0.941

   

0.778

0.169 - 3.577

0.747

 CT + TT

40 (26.8 %)

46 (28.8 %)

0.8

   

0.910

0.553 - 1.498

0.711

 MAF

0.14

0.15

1

0.16

1

1

   

LDLR, rs2228671

        

0.716

 No of pts (n)

149

160

       

 CC

124 (83.2 %)

130 (81.2 %)

       

 CT

22 (14.8 %)

28 (17.5 %)

    

0.824

0.447 - 1.516

0.533

 TT

3 (2 %)

2 (1.2 %)

0.679

   

1.579

0.259 - 9.617

0.620

 CT + TT

25 (16.9 %)

30 (18.8 %)

0.659

   

0.874

0.487 - 1.569

0.651

 MAF

0.09

0.1

1

0.1

1

1

   
  1. p = chi-square test
  2. GP general population, CZ Czech
  3. athe confidence interval - for rs1803274 homozygotes AA vs. GG is too wide. Therefore the data were analyzed only in the setting of a dominant model
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