Table 2 Effect of intramyocardial TSC-22 gene delivery on cardiac function in the normal adult rat heart

Interventricular septum diastole (mm)

LacZ

1.9 ± 0.1

2.0 ± 0.1

TSC-22

2.1 ± 0.1

2.0 ± 0.1

Interventricular septum systole (mm)

LacZ

2.6 ± 0.1

2.5 ± 0.2

TSC-22

2.7 ± 0.2

2.8 ± 0.2

Left ventricle diastole (mm)

LacZ

7.6 ± 0.3

8.6 ± 0.1

TSC-22

7.2 ± 0.3

8.7 ± 0.2

Left ventricle systole (mm)

LacZ

5.1 ± 0.3

6.1 ± 0.3

TSC-22

4.7 ± 0.3

6.1 ± 0.3

Posterior wall distole (mm)

LacZ

2.3 ± 0.2

1.6 ± 0.1

TSC-22

2.0 ± 0.3

1.5 ± 0.1

Posterior wall systole (mm)

LacZ

2.1 ± 0.2

2.3 ± 0.2

TSC-22

2.1 ± 0.1

2.3 ± 0.1

Ejection fraction (%)

LacZ

66.7 ± 2.3

58.2 ± 4.5

TSC-22

69.1 ± 3.0

62.8 ± 3.0

Fractional shortening (%)

LacZ

32.8 ± 1.7

27.4 ± 2.7

TSC-22

34.7 ± 2.5

30.3 ± 2.0

IVRT

LacZ

no data

24.8 ± 2.2

TSC-22

no data

25.0 ± 1.6

E/A-ratio

LacZ

no data

5.1 ± 0.8

TSC-22

no data

2.7 ± 0.6*

n = 7–8

n = 5