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Table 2 Effect of intramyocardial TSC-22 gene delivery on cardiac function in the normal adult rat heart

From: TSC-22 up-regulates collagen 3a1 gene expression in the rat heart

Variable Group TSC-22 TSC-22
   3 days 2 weeks
Interventricular septum diastole (mm) LacZ 1.9 ± 0.1 2.0 ± 0.1
TSC-22 2.1 ± 0.1 2.0 ± 0.1
Interventricular septum systole (mm) LacZ 2.6 ± 0.1 2.5 ± 0.2
TSC-22 2.7 ± 0.2 2.8 ± 0.2
Left ventricle diastole (mm) LacZ 7.6 ± 0.3 8.6 ± 0.1
TSC-22 7.2 ± 0.3 8.7 ± 0.2
Left ventricle systole (mm) LacZ 5.1 ± 0.3 6.1 ± 0.3
TSC-22 4.7 ± 0.3 6.1 ± 0.3
Posterior wall distole (mm) LacZ 2.3 ± 0.2 1.6 ± 0.1
TSC-22 2.0 ± 0.3 1.5 ± 0.1
Posterior wall systole (mm) LacZ 2.1 ± 0.2 2.3 ± 0.2
TSC-22 2.1 ± 0.1 2.3 ± 0.1
Ejection fraction (%) LacZ 66.7 ± 2.3 58.2 ± 4.5
TSC-22 69.1 ± 3.0 62.8 ± 3.0
Fractional shortening (%) LacZ 32.8 ± 1.7 27.4 ± 2.7
TSC-22 34.7 ± 2.5 30.3 ± 2.0
IVRT LacZ no data 24.8 ± 2.2
TSC-22 no data 25.0 ± 1.6
E/A-ratio LacZ no data 5.1 ± 0.8
TSC-22 no data 2.7 ± 0.6*
   n = 7–8 n = 5
  1. Adenoviral gene construct expressing TSC-22 or LacZ were injected into LV free wall and echocardiographic measurements were performed at 3 days and 2 weeks after gene transfer. The results are expressed as mean ± SEM. *P < 0.05 versus LacZ (Student’s t-test). IVRT, isovolumic relaxation time