N-Acetyl Cysteine improves the diabetic cardiac function: possible role of fibrosis inhibition

Table 1 Physiological parameters of mice in all groups

	Initial weight	Terminal weight	HW	HWI	HR
	(g)	(g)	(mg)	(mg/kg, %)	(bpm)
Control	24.32 ± 1.89	27.56 ± 2.33	168.12 ± 8.37	6.11 ± 0.22	446 ± 11
NAC only	23.44 ± 0.89	25.40 ± 0.54	160.40 ± 7.12	6.31 ± 0.21	448 ± 9
NAC1	23.22 ± 1.02	24.54 ± 0.65^*	150.56 ± 7.07^*△	6.10 ± 0.18^△	445 ± 14
NAC3	23.67 ± 2.03	24.36 ± 1.91^*	144.32 ± 13.42^*	5.80 ± 0.25^*	453 ± 21
NAC5	24.72 ± 1.31	24.45 ± 0.97^*	144.00 ± 5.48^*	5.78 ± 0.23^*	440 ± 11
NAC7	24.86 ± 1.96	24.92 ± 1.83^*	143.57 ± 8.94^*	5.77 ± 0.14^*	451 ± 19
DM	24.19 ± 1.60	24.84 ± 0.79^*	138.00 ± 4.47^*	5.56 ± 0.26^*	441 ± 9
p value^a	0.347	0.940	0.668	0.066	0.61

Notes: No significant differences were found between control and NAC only group; ^*Compared with control, p < 0.05; ^△NAC treatment groups compared with DM group, p < 0.05; No significant difference was seen in initial weight and heart rate among all groups. a, ANOVA test among the NAC1, NAC3, NAC5 and NAC7 four groups, no significant difference was seen among the four groups. HW, heart weight; HWI, heart weight index; HR, heart rate. (n = 5 in each group)

ISSN: 1471-2261