Fig. 2

Forest Plot for Composite Cardiovascular Outcome. Individual and pooled risk ratios (RR) with 95 % confidence intervals (CI) for randomized controlled trials (RCTs) enrolling patients with cardiovascular diseases comparing colchicine to placebo or control. The pooled RRs with 95 % CI were calculated using random-effects models. Weight refers to the contribution of each study to the overall pooled estimate of treatment effect. Each square and horizontal line denotes the point estimate and 95 % CI for each trial’s RR. The diamonds signify the pooled RR; the diamond’s centre denotes the point estimate and width denotes the 95 % CI. The composite cardiovascular outcome includes the components indicated for each RCT, except for Nidorf 2013 [14] also includes cardiac arrests. Abbreviations: ACS, acute coronary syndrome; CI, confidence interval; CVA, cerebrovascular attack; IV, inverse variance; MI, myocardial infarction; revasc, revascularization