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Table 2 Summary of outcomes of the included studies

From: Image-guided left ventricular lead placement in cardiac resynchronization therapy for patients with heart failure: a meta-analysis

First author (year) CRT intervention Concordance of LV lead to latest site of activation, % OR for CRT response (95 % CI) CRT response, count (%) LVESV (ml), mean ± SD Change from baseline LVEF (%), mean ± SD All-cause mortality, count (%) HF-related hospitalization, count (%)
Baseline Post treatment Baseline Post treatment Change from baseline
Saba (2013) [43] Image-guided Exact/adjacent: NR 50 (57 %) 140 ± 59 NR −30 ± 29 (%)a 26 ± 6 38 ± 12.8b 12 ± 11 15 (13.6 %) 16 (14.5 %)
30/NR
Exact or adjacent: 85
Remote: 15
Standard Exact/adjacent: 22 (35 %) 144 ± 63 NR −20 ± 25 (%)a 26 ± 7 35 ± 11.45b 9 ± 10 15 (19.5 %) 21 (27.3 %)
12/NR
Exact or adjacent: 66
Remote: 33
Khan (2012) [42] Image-guided Exact/adjacent: 1.92 (1.08, 3.39) 72 (70 %) 157 ± 56 111 ± 43 −46 ± 33 (ml) 23 ± 6 31 ± 9 8 ± 7 22 (10 %) 18 (8 %)
63/26
Exact or adjacent: NR
Remote: 10
Standard Exact/adjacent: 1.0 (reference) 57 (55 %) 154 ± 52 128 ± 50 −26 ± 23 (ml) 23 ± 7 28 ± 10 5 ± 8  
47/29
Exact or adjacent: NR
Remote: 25
Bai (2011) [44] Image-guided NR 2.68 (1.08-6.65)c 41 (82 %) 172 ± 65 129 ± 65 −43 ± 65 (ml) 23 ± 7 34 ± 10 11 ± 8.89d NR NR
Standard NR 1.0 (reference) 34 (63 %) 159 ± 74 141 ± 82 −18 ± 78 (ml) 26 ± 6 32 ± 9 6 ± 7.94d NR NR
  1. Abbreviations: CRT cardiac resynchronization therapy, LV left ventricular, EF ejection fraction, LVESV left ventricular end-systolic volume, ml milliliters, SD standard deviation, NR not reported, HF heart failure
  2. aRepresented as a relative change before and after treatment
  3. bData were estimated according to the reported results of baseline and change from baseline; n = 87 for the image-guided group and n = 62 for the standard group
  4. cWith adjustment for clinical characteristics
  5. dData were estimated according to the reported LVEF at baseline and post-treatment