Image-guided left ventricular lead placement in cardiac resynchronization therapy for patients with heart failure: a meta-analysis

Table 2 Summary of outcomes of the included studies

First author (year)	CRT intervention	Concordance of LV lead to latest site of activation, %	OR for CRT response (95 % CI)	CRT response, count (%)	LVESV (ml), mean ± SD		Change from baseline	LVEF (%), mean ± SD			All-cause mortality, count (%)	HF-related hospitalization, count (%)
First author (year)	CRT intervention	Concordance of LV lead to latest site of activation, %	OR for CRT response (95 % CI)	CRT response, count (%)	Baseline	Post treatment	Change from baseline	Baseline	Post treatment	Change from baseline	All-cause mortality, count (%)	HF-related hospitalization, count (%)
Saba (2013) [43]	Image-guided	Exact/adjacent:	NR	50 (57 %)	140 ± 59	NR	−30 ± 29 (%)^a	26 ± 6	38 ± 12.8^b	12 ± 11	15 (13.6 %)	16 (14.5 %)
		30/NR
		Exact or adjacent: 85
		Remote: 15
	Standard	Exact/adjacent:		22 (35 %)	144 ± 63	NR	−20 ± 25 (%)^a	26 ± 7	35 ± 11.45^b	9 ± 10	15 (19.5 %)	21 (27.3 %)
		12/NR
		Exact or adjacent: 66
		Remote: 33
Khan (2012) [42]	Image-guided	Exact/adjacent:	1.92 (1.08, 3.39)	72 (70 %)	157 ± 56	111 ± 43	−46 ± 33 (ml)	23 ± 6	31 ± 9	8 ± 7	22 (10 %)	18 (8 %)
		63/26
		Exact or adjacent: NR
		Remote: 10
	Standard	Exact/adjacent:	1.0 (reference)	57 (55 %)	154 ± 52	128 ± 50	−26 ± 23 (ml)	23 ± 7	28 ± 10	5 ± 8
		47/29
		Exact or adjacent: NR
		Remote: 25
Bai (2011) [44]	Image-guided	NR	2.68 (1.08-6.65)^c	41 (82 %)	172 ± 65	129 ± 65	−43 ± 65 (ml)	23 ± 7	34 ± 10	11 ± 8.89^d	NR	NR
Bai (2011) [44]	Standard	NR	1.0 (reference)	34 (63 %)	159 ± 74	141 ± 82	−18 ± 78 (ml)	26 ± 6	32 ± 9	6 ± 7.94^d	NR	NR

Abbreviations: CRT cardiac resynchronization therapy, LV left ventricular, EF ejection fraction, LVESV left ventricular end-systolic volume, ml milliliters, SD standard deviation, NR not reported, HF heart failure
^aRepresented as a relative change before and after treatment
^bData were estimated according to the reported results of baseline and change from baseline; n = 87 for the image-guided group and n = 62 for the standard group
^cWith adjustment for clinical characteristics
^dData were estimated according to the reported LVEF at baseline and post-treatment

ISSN: 1471-2261