Skip to main content

Table 4 Multivariable Cox Regression analyses for all-cause mortality and AHF related rehospitalization at 5 years in AHF patients (n = 122)

From: Ischemic biomarker heart-type fatty acid binding protein (hFABP) in acute heart failure - diagnostic and prognostic insights compared to NT-proBNP and troponin I

  All-cause mortality AHF-related reospitalization
  hFABP Troponin I hFABP Troponin I
  HR 95 % CI p Value HR 95 % CI p Value HR 95 % CI p Value HR 95 % CI p Value
Age 1.056 1.025–1.088 0.001 1.060 1.029–1.092 0.001 1.027 0.997–1.058 0.079 1.032 1.002–1.062 0.039
Sex 1.096 0.573–2.098 0.783 0.657 0.317–1.362 0.259 1.354 0.651–2.815 0.418 1.548 0.742–3.230 0.244
NYHA functional class 0.942 0.619–1.433 0.780 0.501 0.075–3.333 0.475 1.610 1.001–2.592 0.049 0.798 0.059–10.61 0.864
Left ventricular function 1.263 0.926–1.724 0.141 1.450 1.040–2.021 0.028 1.227 0.875–1.720 0.236 1.167 0.836–1.628 0.364
Coronary artery disease 0.812 0.423–1.561 0.532 0.893 0.461–1.727 0.736 1.140 0.559–2.323 0.718 1.133 0.558–2.302 0.731
Diabetes mellitus 1.163 0.622–2.178 0.635 1.172 0.625–2.198 0.620 1.324 0.682–2.570 0.408 1.202 0.623–2.317 0.584
Creatinine (mg/dl) 0.952 0.463–1.954 0.892 1.234 0.597–2.547 0.571 0.400 0.159–1.003 0.051 0.448 0.187–1.073 0.072
Sodium (mmol/l) 0.978 0.920–1.039 0.463 0.967 0.910–1.026 0.264 1.113 1.023–1.211 0.013 1.123 1.030–1.225 0.008
Hemoglobin (g/dl) 0.836 0.701–0.998 0.047 0.827 0.694–0.986 0.034 0.949 0.792–1.139 0.576 0.934 0.780–1.117 0.453
ACEI/ARB treatment 0.919 0.498–1.701 0.790 1.005 0.544–1.859 0.987 1.425 0.722–2.812 0.307 1.501 0.758–2.974 0.244
Beta-blocker treatment 0.895 0.488–1.644 0.721 0.826 0.451–1.511 0.535 1.387 0.704–2.732 0.345 1.550 0.795–3.023 0.198
LogNT-proBNP (ng/l) 1.207 0.911–1.601 0.190 1.324 0.997–1.757 0.052 0.911 0.696–1.192 0.496 1.015 0.780–1.320 0.912
hFABP (10 ng/ml) 0.996 0.948–1.047 0.873 - - - 1.073 1.018–1.132 0.008 - - -
Troponin I (μg/l) - - - 0.789 0.567–1.071 0.125 - - - 0.982 0.914–1.055 0.620
  1. The logarithmic function of NT-proBNP and hFABP per every 10 ng/ml change were used in Cox Models. Significant p values (p<0.05) are written in bold type. Dashes indicate non applicable
  2. HR hazard ratio, CI confidence interval