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Table 4 Multivariable Cox Regression analyses for all-cause mortality and AHF related rehospitalization at 5 years in AHF patients (n = 122)

From: Ischemic biomarker heart-type fatty acid binding protein (hFABP) in acute heart failure - diagnostic and prognostic insights compared to NT-proBNP and troponin I

 

All-cause mortality

AHF-related reospitalization

 

hFABP

Troponin I

hFABP

Troponin I

 

HR

95 % CI

p Value

HR

95 % CI

p Value

HR

95 % CI

p Value

HR

95 % CI

p Value

Age

1.056

1.025–1.088

0.001

1.060

1.029–1.092

0.001

1.027

0.997–1.058

0.079

1.032

1.002–1.062

0.039

Sex

1.096

0.573–2.098

0.783

0.657

0.317–1.362

0.259

1.354

0.651–2.815

0.418

1.548

0.742–3.230

0.244

NYHA functional class

0.942

0.619–1.433

0.780

0.501

0.075–3.333

0.475

1.610

1.001–2.592

0.049

0.798

0.059–10.61

0.864

Left ventricular function

1.263

0.926–1.724

0.141

1.450

1.040–2.021

0.028

1.227

0.875–1.720

0.236

1.167

0.836–1.628

0.364

Coronary artery disease

0.812

0.423–1.561

0.532

0.893

0.461–1.727

0.736

1.140

0.559–2.323

0.718

1.133

0.558–2.302

0.731

Diabetes mellitus

1.163

0.622–2.178

0.635

1.172

0.625–2.198

0.620

1.324

0.682–2.570

0.408

1.202

0.623–2.317

0.584

Creatinine (mg/dl)

0.952

0.463–1.954

0.892

1.234

0.597–2.547

0.571

0.400

0.159–1.003

0.051

0.448

0.187–1.073

0.072

Sodium (mmol/l)

0.978

0.920–1.039

0.463

0.967

0.910–1.026

0.264

1.113

1.023–1.211

0.013

1.123

1.030–1.225

0.008

Hemoglobin (g/dl)

0.836

0.701–0.998

0.047

0.827

0.694–0.986

0.034

0.949

0.792–1.139

0.576

0.934

0.780–1.117

0.453

ACEI/ARB treatment

0.919

0.498–1.701

0.790

1.005

0.544–1.859

0.987

1.425

0.722–2.812

0.307

1.501

0.758–2.974

0.244

Beta-blocker treatment

0.895

0.488–1.644

0.721

0.826

0.451–1.511

0.535

1.387

0.704–2.732

0.345

1.550

0.795–3.023

0.198

LogNT-proBNP (ng/l)

1.207

0.911–1.601

0.190

1.324

0.997–1.757

0.052

0.911

0.696–1.192

0.496

1.015

0.780–1.320

0.912

hFABP (10 ng/ml)

0.996

0.948–1.047

0.873

-

-

-

1.073

1.018–1.132

0.008

-

-

-

Troponin I (μg/l)

-

-

-

0.789

0.567–1.071

0.125

-

-

-

0.982

0.914–1.055

0.620

  1. The logarithmic function of NT-proBNP and hFABP per every 10 ng/ml change were used in Cox Models. Significant p values (p<0.05) are written in bold type. Dashes indicate non applicable
  2. HR hazard ratio, CI confidence interval