Body weight in midlife and long-term risk of developing heart failure-a 35-year follow-up of the primary prevention study in Gothenburg, Sweden

Table 2 Lifetime risk of developing heart failure in 7,495 men by body mass index (BMI) with or without ischemic heart disease

	Number at risk	HF events	Observation years	Incidence rate per 1000 observations years	Age adjusted SHR	Multivariable adjusted^aSHR	Multivariable adjusted^bSHR
	n = 7494	HF events	Observation years	Incidence rate per 1000 observations years	(95% CI)	(95% CI)	(95% CI)
All HF events (n = 1855)
BMI
<22.5	1182	234	29473	7.94	1.00 (ref)	1.00 (ref)	1.00 (ref)
22.5-24.99	2266	533	59057	9.03	1.20 (1.02-1.39)	1.19 (1.02-1.39)	1.16 (0.99-1.36)
25-27.49	2222	562	57564	9.76	1.29 (1.11-1.50)	1.30 (1.11-1.52)	1.26 (1.07-1.47)
27.5-29.9	1207	342	29864	11.45	1.50 (1.27-1.77)	1.51 (1.28-1.79)	1.44 (1.21-1.71)
≥30	617	184	13976	13.17	1.62 (1.33-1.97)	1.61 (1.32-1.96)	1.51 (1.23-1.85)
HF without IHD (n = 851)
BMI
<22.5	1182	117	29888	3.91	1.00 (ref)	1.00 (ref)	1.00 (ref)
22.5-24.99	2266	251	60084	4.18	1.11 (0.89-1.38)	1.08 (0.87-1.35)	1.11 (0.88-1.38)
25-27.49	2222	247	58580	4.22	1.11 (0.89-1.38)	1.10 (0.89-1.37)	1.14 (0.91-1.43)
27.5-29.9	1207	153	30603	5.00	1.28 (1.01-1.63)	1.28 (1.00-1.63)	1.38 (1.07-1.77)
≥30	617	83	14352	5.78	1.39 (1.05-1.84)	1.39 (1.04-1.85)	1.52 (1.13-2.04)
HF and IHD (n = 1004)
BMI
<22.5	1182	117	29785	3.93	1.00 (ref)	1.00 (ref)	1.00 (ref)
22.5-24.9	2266	282	59844	4.71	1.26 (1.02-1.57)	1.28 (1.02-1.58)	1.20 (0.97-1.50)
25-27.49	2222	315	58386	5.40	1.44 (1.17-1.79)	1.47 (1.18-1.83)	1.34 (1.07-1.67)
27.5-29.9	1207	189	30440	6.21	1.62 (1.29-2.04)	1.65 (1.30-2.08)	1.43 (1.12-1.81)
≥30	617	101	14354	7.04	1.72 (1.32-2.25)	1.69 (1.29-2.23)	1.41 (1.07-1.86)

^aAdjusted for age, IHD, smoking, physical activity and occupational status.
^bAdjusted for age, IHD, smoking, physical activity, occupational class, total serum cholesterol, diabetes, systolic blood pressure and hypertension.
^cIHD defined as acute myocardial infarction or revascularization (coronary artery bypass grafting (CABG) or percutaneus coronary intervention (PCI)).
HF indicates heart failure; BMI, body mass index; SHR, subdistribution hazard ratio and IHD, ischemic heart disease.

ISSN: 1471-2261