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Table 2 Lifetime risk of developing heart failure in 7,495 men by body mass index (BMI) with or without ischemic heart disease

From: Body weight in midlife and long-term risk of developing heart failure-a 35-year follow-up of the primary prevention study in Gothenburg, Sweden

  Number at risk HF events Observation years Incidence rate per 1000 observations years Age adjusted SHR Multivariable adjustedaSHR Multivariable adjustedbSHR
n = 7494 (95% CI) (95% CI) (95% CI)
All HF events (n = 1855)        
BMI        
<22.5 1182 234 29473 7.94 1.00 (ref) 1.00 (ref) 1.00 (ref)
22.5-24.99 2266 533 59057 9.03 1.20 (1.02-1.39) 1.19 (1.02-1.39) 1.16 (0.99-1.36)
25-27.49 2222 562 57564 9.76 1.29 (1.11-1.50) 1.30 (1.11-1.52) 1.26 (1.07-1.47)
27.5-29.9 1207 342 29864 11.45 1.50 (1.27-1.77) 1.51 (1.28-1.79) 1.44 (1.21-1.71)
≥30 617 184 13976 13.17 1.62 (1.33-1.97) 1.61 (1.32-1.96) 1.51 (1.23-1.85)
HF without IHD (n = 851)        
BMI        
<22.5 1182 117 29888 3.91 1.00 (ref) 1.00 (ref) 1.00 (ref)
22.5-24.99 2266 251 60084 4.18 1.11 (0.89-1.38) 1.08 (0.87-1.35) 1.11 (0.88-1.38)
25-27.49 2222 247 58580 4.22 1.11 (0.89-1.38) 1.10 (0.89-1.37) 1.14 (0.91-1.43)
27.5-29.9 1207 153 30603 5.00 1.28 (1.01-1.63) 1.28 (1.00-1.63) 1.38 (1.07-1.77)
≥30 617 83 14352 5.78 1.39 (1.05-1.84) 1.39 (1.04-1.85) 1.52 (1.13-2.04)
HF and IHD (n = 1004)        
BMI        
<22.5 1182 117 29785 3.93 1.00 (ref) 1.00 (ref) 1.00 (ref)
22.5-24.9 2266 282 59844 4.71 1.26 (1.02-1.57) 1.28 (1.02-1.58) 1.20 (0.97-1.50)
25-27.49 2222 315 58386 5.40 1.44 (1.17-1.79) 1.47 (1.18-1.83) 1.34 (1.07-1.67)
27.5-29.9 1207 189 30440 6.21 1.62 (1.29-2.04) 1.65 (1.30-2.08) 1.43 (1.12-1.81)
≥30 617 101 14354 7.04 1.72 (1.32-2.25) 1.69 (1.29-2.23) 1.41 (1.07-1.86)
  1. aAdjusted for age, IHD, smoking, physical activity and occupational status.
  2. bAdjusted for age, IHD, smoking, physical activity, occupational class, total serum cholesterol, diabetes, systolic blood pressure and hypertension.
  3. cIHD defined as acute myocardial infarction or revascularization (coronary artery bypass grafting (CABG) or percutaneus coronary intervention (PCI)).
  4. HF indicates heart failure; BMI, body mass index; SHR, subdistribution hazard ratio and IHD, ischemic heart disease.