From: ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model
Study 1 | |||||
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Unoperated (0 NX) | 1/2 NX | 5/6 NX | |||
Variable | Unit | (n = 13) | (n = 18) | (n = 22) | P |
Body weight | g | 26.4 ± 1.6 | 27.6 ± 1.5 | 23.0 ± 3.5a | < 0.0001 |
Mean blood pressure | mmHg | 116.6 ± 6.5 | 113.0 ± 8.2 | 116.8 ± 14.3 | NS |
B-hemoglobin | mmol/L | 8.38 ± 0.55 | 8.26 ± 0.26 | 6.85 ± 0.74a | < 0.0001 |
P-urea | mmol/L | 10.6 ± 1.5 | 12.5 ± 2.1a | 28.0 ± 9.7a | < 0.0001 |
P-creatinine | mmol/L | 0.036 ± 0.005 | 0.038 ± 0.005 | 0.051 ± 0.007a | < 0.0001 |
P-phosphate | mmol/L | 2.20 ± 0.16 | 1.89 ± 0.27a | 2.61 ± 0.72a | < 0.0005 |
P-calcium | mmol/L | 2.22 ± 0.12 | 2.25 ± 0.06 | 2.52 ± 0.12a | < 0.0001 |
P-Ca × P | mmol2/L2 | 4.89 ± 0.43 | 4.24 ± 0.64a | 6.56 ± 1.82a | < 0.0001 |
P-cholesterol | mmol/L | 13.3 ± 1.9 | 15.0 ± 3.6 | 19.3 ± 3.6a | < 0.0001 |
Triglyceride | mmol/L | 0.70 ± 0.37 | 0.58 ± 0.20 | 0.46 ± 0.14a | < 0.01 |
Aortic plaque area fraction | % | 0.048 ± 0.025 | 0.085 ± 0.038a | 0.258 ± 0.117a | < 0.0001 |