Skip to main content

Table 1 Effect of chronic renal failure on body weight, blood pressure, blood hemoglobin, plasma indices of uremia, plasma lipids, and aortic atherosclerosis in Study 1.

From: ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model

Study 1

  

Unoperated (0 NX)

1/2 NX

5/6 NX

 

Variable

Unit

(n = 13)

(n = 18)

(n = 22)

P

Body weight

g

26.4 ± 1.6

27.6 ± 1.5

23.0 ± 3.5a

< 0.0001

Mean blood pressure

mmHg

116.6 ± 6.5

113.0 ± 8.2

116.8 ± 14.3

NS

B-hemoglobin

mmol/L

8.38 ± 0.55

8.26 ± 0.26

6.85 ± 0.74a

< 0.0001

P-urea

mmol/L

10.6 ± 1.5

12.5 ± 2.1a

28.0 ± 9.7a

< 0.0001

P-creatinine

mmol/L

0.036 ± 0.005

0.038 ± 0.005

0.051 ± 0.007a

< 0.0001

P-phosphate

mmol/L

2.20 ± 0.16

1.89 ± 0.27a

2.61 ± 0.72a

< 0.0005

P-calcium

mmol/L

2.22 ± 0.12

2.25 ± 0.06

2.52 ± 0.12a

< 0.0001

P-Ca × P

mmol2/L2

4.89 ± 0.43

4.24 ± 0.64a

6.56 ± 1.82a

< 0.0001

P-cholesterol

mmol/L

13.3 ± 1.9

15.0 ± 3.6

19.3 ± 3.6a

< 0.0001

Triglyceride

mmol/L

0.70 ± 0.37

0.58 ± 0.20

0.46 ± 0.14a

< 0.01

Aortic plaque area fraction

%

0.048 ± 0.025

0.085 ± 0.038a

0.258 ± 0.117a

< 0.0001

  1. Fasting blood samples were obtained at the end of the study, i.e. when the mice were 29 weeks of age. Aortic plaque area fraction was determined by the en face technique. Values are mean ± SD. P-values were calculated using the Kruskal-Wallis test for differences between three groups. Two-group comparisons were performed using the t-test. Statistically significant difference vs. "Unoperated" group is denoted by superscript a.