Table 3 Associations between the PGC1α Gly482Ser polymorphism and diastolic dysfunction, in males and females.
From: The PPARGC1AGly482Ser polymorphism is associated with left ventricular diastolic dysfunction in men
Gly/Gly | Gly/Ser | Ser/Ser | P for trend | |||
|---|---|---|---|---|---|---|
Males | N = 214 | N = 237 | N = 48 | |||
Covariates | OR | OR | (95% CI) | OR | (95%CI) | |
Age | 1.0 | 0.70 | (0.40 – 1.22) | 0.19 | (0.05 – 0.72) | 0.012 |
Age, body mass index | 1.0 | 0.64 | (0.36 – 1.14) | 0.15 | (0.04 – 0.61) | 0.005 |
Age, low leisure-time physical activity | 1.0 | 0.72 | (0.41 – 1.26) | 0.19 | (0.05 – 0.72) | 0.015 |
Age, body mass index, low leisure-time physical activity | 1.0 | 0.66 | (0.37 – 1.17) | 0.16 | (0.04 – 0.66) | 0.007 |
Age, hypertension | 1.0 | 0.70 | (0.40 – 1.22) | 0.19 | (0.05 – 0.72) | 0.012 |
Age, diabetes | 1.0 | 0.67 | (0.38 – 1.19) | 0.16 | (0.04 – 0.63) | 0.007 |
Age, hypertension, diabetes | 1.0 | 0.68 | (0.38 – 1.20) | 0.14 | (0.04 – 0.58) | 0.007 |
Age, body mass index, low leisure-time physical activity, hypertension, diabetes | 1.0 | 0.62 | (0.34 – 1.13) | 0.13 | (0.03 – 0.54) | 0.004 |
Gly/Gly | Gly/Ser | Ser/Ser | P for trend | |||
Females | N = 229 | N = 243 | N = 61 | |||
Covariates | OR | OR | (95% CI) | OR | (95%CI) | |
Age | 1.0 | 1.31 | (0.68 – 2.55) | 0.30 | (0.06 – 1.45) | 0.533 |
Age, BMI | 1.0 | 1.22 | (0.61 – 2.41) | 0.33 | (0.07 – 1.60) | 0.495 |
Age, low leisure-time physical activity | 1.0 | 1.39 | (0.71 – 2.73) | 0.31 | (0.06 – 1.49) | 0.603 |
Age, body mass index, low leisure-time physical activity | 1.0 | 1.29 | (0.64 – 2.58) | 0.33 | (0.07 – 1.62) | 0.550 |
Age, hypertension | 1.0 | 1.31 | (0.67 – 2.53) | 0.30 | (0.06 – 1.47) | 0.529 |
Age, diabetes | 1.0 | 1.38 | (0.70 – 2.72) | 0.33 | (0.07 – 1.60) | 0.622 |
Age, hypertension, diabetes | 1.0 | 1.68 | (0.82 – 3.44) | 0.32 | (0.06 – 1.59) | 0.777 |
Age, body mass index, low leisure-time physical activity, hypertension, diabetes | 1.0 | 1.60 | (0.77 – 3.35) | 0.35 | (0.07 – 1.69) | 0.740 |