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Table 5 Haplotype combination analyses of G482S and +2962A/G for regular and severe hypertension in 1642 participants

From: The impact of severity of hypertension on association of PGC-1αGene with blood pressure and risk of hypertension

  

Regular hypertension*

Severe hypertension**

 

Haplotype combinations

N

Cases

Prevalence,%

OR1(95%CI)

Cases

Prevalence,%

OR2(95%CI)

p values for OR1 vs. OR2

S482S||+2962A/X

316

147

46.5%

1

38

12.0%

1.0

 

S482S||+2962G/G

0

0

0

 

0

0

  

G482X||+2962A/X

1165

569

48.8%

1.0(0.8–1.3)

192

16.5%

1.5(1.0–2.2)

0.131

G482X||+2962G/G

161

79

49.1%

1.0(0.7–1.5)

38

23.6%

2.6(1.5–4.4)

0.006

p values

  

0.753

0.989

 

0.005

0.002

 
  1. * Regular hypertension: SBP ≧ 140 mm Hg or DBP ≧ 90mm Hg or current use of antihypertensive medications;
  2. ** Severe hypertension: SBP ≧ 160 mm Hg or DBP ≧ 100mm Hg, regardless of medication use.
  3. OR1: adjusted for sex, age, BMI.
  4. OR2: adjusted for sex, age, BMI, and antihypertensive medication.
  5. X was used to represents all possible allele, e.g. +2962A/X stands for +2962A/A or +2962A/G.
  6. P values for prevalence were from Chi-square test, p values for trend of ORs were from logistic regression, and p values for OR1 vs. OR2 were from Z-test.
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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