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Table 4 Prevalence and odds ratios (ORs) of regular and severe hypertension by PGC-1α polymorphisms in 1642 participants

From: The impact of severity of hypertension on association of PGC-1αGene with blood pressure and risk of hypertension

  

Regular hypertension*

Severe hypertension**

 

Genotypes

Total No.

Cases

Prevalence,%

OR1(95%CI)

Cases

Prevalence,%

OR2(95%CI)

p values for OR1 vs. OR2

G482S genotypes

        

   G482G

511

261

51.1%

1.0

91

17.8%

1.0

 

   G482S

815

387

47.5%

0.9(0.7–1.1)

139

17.1%

1.0(0.8–1.4)

0.503

   S482S

316

147

46.5%

0.9(0.7–1.2)

38

12.0%

0.6(0.4–0.98)

0.177

   p values

  

0.335

0.667

 

0.067

0.064

 

+2962A/G genotypes

        

   +2962A/A

840

411

48.9%

1.0

128

15.2%

1.0

 

   +2962A/G

641

305

47.6%

0.9(0.7–1.1)

102

15.9%

1.1(0.8–1.4)

0.407

   +2962G/G

161

79

49.1%

0.9(0.7–1.4)

38

23.6%

1.9(1.2–3.0)

0.015

   p values

  

0.863

0.623

 

0.030

0.011

 
  1. * Regular hypertension: SBP ≧ 140 mm Hg or DBP ≧ 90mm Hg or current use of antihypertensive medications;
  2. ** Severe hypertension: SBP ≧ 160 mm Hg or DBP ≧ 100mm Hg, regardless of medication use.
  3. OR1: adjusted for sex, age, BMI.
  4. OR2: adjusted for sex, age, BMI, and antihypertensive medication.
  5. P values for prevalence were from Chi-square test, p values for trend of ORs were from logistic regression, and p values for OR1 vs. OR2 were from Z-test.
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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