Figure 1

Steps to increase doses of study drug and antihypertensivedrugs other than the study drug and to use other concomitant drug. 1) In the case in which the systolic blood pressure (mean level of the levels measured for last 5 days) measured at home after getting up for a week after the start of observation period is > 180 mm Hg or the diastolic blood pressure level is > 110 mm Hg, the case may be assigned to the treated group. 2, 3) Only when the blood pressure level does not reach the target systolic and diastolic blood pressure measured at home after getting up are < 125 mm Hg and < 80 mm Hg, respectively). 2) The combined use of renin-angiotensin inhibitors (ACE inhibitors, AII antagonist) is prohibited. 3) The combined use of calcium channel blocker is prohibited.