Table 4 Summary of heritability estimates of left ventricular mass trait
Author, year | Study design | Study population origins | Numbers of families/subjects | Adjusted covariate | Heritability estimate (h2) | Comments |
|---|---|---|---|---|---|---|
Post et al. 1997 15 | Relative pairs | Caucasians, Framingham families, no systemic diseases | 2624 subjects | Age, height, weight, systolic blood pressure | 0.24–0.32 | Limit in subjects without systemic diseases nor medication history |
Garner et al. 2000 13 | Nuclear families | White, European families | 149/624 | weight | 0.28 | Children population |
Kotchen et al. 2000 19 | Sibling | African American, hypertensive, hyperlipidemia | 68 sibpairs | Age, gender | 0.65–0.72 | FCOR and ASSOC in SAGE program to perform the analysis |
Arnett et al. 2001 16 | Sibling | African Americans & white hypertensive | 1664 siblings | Age, gender, systolic blood pressure, obesity | Sibling correlations 0.29–0.44 in African American, 0.04–0.12 in white | High sibling correlation in African Americans |
Palatini et al. 2001 23 | Nuclear families | Tecumseh Offspring Study | 251 offspring and 290 parents | Age, gender, body height systolic blood pressure, insulin, urinary sodium excretion, | No estimate of h2, parental LV mass explained 7.6% of total variance of offspring LV mass | Multiple linear regression models Young offspring (mean 17 years old) |
Mayosi et al. 2002 17 | Extended families | British Caucasians, hypertensive probands from hospital or clinics | 229/955 | Age, systolic blood pressure, weight, height, WHR, diabetes | 0.23–0.29 | Ascertainment correction: yes |
Swan et al. 2003 18 | Twins | Caucasians, Population-based | 55 pairs MZ vs. 55 pairs DZ | Age, gender, blood pressure, weight | 0.53–0.69 | |
Bella et al. 2004 12 | Relative pairs, mostly sibpairs | American Indian families, different geographic location | 455/1373, 1305 relative pairs, 1077 sibpairs | Age, gender, centers, weight, height, systolic blood pressure, heart rate, medication, diabetes | 0.17(multiple adjusted) -0.27 (first three variates adjusted) | No significant heritability in Arizona Indians |
Juo et al. 2005 20 | Extended families | Caribbean Hispanics | 84/623 | Age, gender, weight | 0.51 | Adding systolic blood pressure, diabetes, medication did not affect the estimate |
This report | Nuclear families | Ethnic Chinese, young probands, community-based | 368/1145 | Age, gender, body mass index, blood pressure | 0.15 (multiple adjusted) -0.27 (first 3 variates adjusted) |