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Table 5 Hepatic HMG-CoA reductase, ACAT and cholesterol 7α-hydroxylase activities (CYP7) guinea pigs fed a control diet, low dose MTPi (LDI), high dose MTPi (HDI) or atorvastatin1

From: JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs

Diets

HMG-CoA Reductase

ACAT

CYP7

  

(pmol/min.mg)

 

Control

1.8 ± 0.8

0.8 ± 0.4

1.7 ± 1.8

LDI

2.7 ± 0.8

2.2 ± 0.9

1.2 ± 0.5

HDI

2.5 ± 1.4

3.5 ± 2.4

0.6 ± 0.7

Atorvastatin

3.4 ± 2.9

4.4 ± 3.1

0.7 ± 0.4

  1. 1Data are presented as mean ± SD for n = 3–7 guinea pigs per group.
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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