Figure 2

Fluvastatin inhibits TF expression in SMC. In human saphenous vein SMC (HSVSMC, panel A, n = 4) as well as in human aortic SMC (HAoSMC, panel B, n = 4) sirolimus (20 ng/ml, 24 hours) up-regulated TF expression which was significantly inhibited by fluvastatin (1 μmol/L). Basal activity of RhoA was not influenced by sirolimus (20 ng/ml, n = 3, panel C), while the basal activity of mTOR was fully inhibited by sirolimus (20 ng/ml, 1 hour, n = 3, panel D). * = p < 0.01 vs. control, ^† = p < 0.05 vs. sirolimus.