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Table 1 Characteristics of Included Studies

From: Are antifibrinolytic drugs equivalent in reducing blood loss and transfusion in cardiac surgery? A meta-analysis of randomized head-to-head trials

Study

Year

Country

Type of cardiac surgery

Interventions

Isetta et al. [25]

1993

France

NR

HD APR (n = 70) vs. LD APR (n = 70) vs. TXA (n = 70) vs. Control (n = 70)

Blauhut et al. [27]

1994

Switzerland

CABG

HD APR (n = 14) vs. TXA (n = 14) vs. Control (n = 14)

Penta de Peppo et al. [20]

1995

Italy

CABG & Valve Sx.

HD APR (n = 15) vs. TXA (n = 15) vs. EACA (n = 15) vs. Control (n = 15)

Corbeau et al. [23]

1995

France

CABG & Valve Sx.

HD APR (n = 43) vs. TXA (n = 41) vs. Control (n = 20)

Pugh et al. [22]

1995

UK

Primary CABG

LD APR (n = 21) vs. TXA (n = 22) vs. Control (n = 23)

Speekenbrink et al. [21]

1995

The Netherlands

Primary CABG

PP APR (n = 15) vs. TXA (n = 15) vs. DIP (n = 12) vs. Control (n = 15)

Menichetti et al. [24]

1996

Italy

Primary CABG

HD APR (n = 24) vs. TXA (n = 24) vs. EACA (n = 24) vs. Control (n = 24)

Pinosky et al. [33]

1997

USA

Primary CABG

TXA (n = 20) vs. EACA (n = 20) vs. Placebo (n = 19)

Mongan et al. [31]

1998

USA

Primary CABG

HD APR (n = 75) vs. TXA (n = 75)

Hardy et al. [26]

1998

Canada

Primary CABG

TXA (n = 42) vs. EACA (n = 46) vs. Placebo (n = 44)

Eberle et al. [29]

1998

Germany

Primary CABG

HD APR (n = 20) vs. EACA (n = 20)

Misfeld et al. [30]

1998

Germany

Primary CABG

LD APR (n = 14) vs. TXA (n = 14) vs. Control (n = 14)

Casati et al. [28]

1999

Italy

Primary CABG & Valve Sx.

HD APR (n = 67) vs. TXA (n = 70) vs. EACA (n = 66)

Bernet et al. [34]

1999

Switzerland

Primary CABG

HD APR (n = 28) vs. TXA (n = 28)

Nuttall et al. [32]

2000

USA

Re-do CABG & Valve Sx.

HD APR (n = 40) vs. TXA (n = 45) vs. TXA+ANH (n = 32) vs Placebo (n = 43)

Maineri et al. [38]

2000

Italy

Primary CABG

TXA (n = 24) vs. EACA (n = 24)

Wong et al. [37]

2000

Canada

Re-do CABG & Valve Sx.

HD APR (n = 39) vs. TXA (n = 38)

Casati et al. [35]

2000

Italy

Primary CABG & Valve & ASD Repair

HD APR (n = 518) vs. TXA (n = 522)

Greilich et al. [36]

2001

USA

Primary CABG

HD APR (n = 24) vs. EACA (n = 23) vs. Placebo (n = 25)

Ray et al. [6]

2001

Australia

CABG & Valve Sx.

LD APR (n = 49) vs. EACA (n = 51)

  1. ANH = acute normovolemic hemodilution, APR = aprotinin, ASD = atrial septal defect, CABG = coronary artery bypass graft, DIP = dipyridamole, EACA = epsilon aminocaproic acid, HD = high dose, LD = low dose, NR = not reported, PP = pump prime, Sx. = surgery, TXA = tranexamic acid