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Table 1 Characteristics of Included Studies

From: Are antifibrinolytic drugs equivalent in reducing blood loss and transfusion in cardiac surgery? A meta-analysis of randomized head-to-head trials

Study Year Country Type of cardiac surgery Interventions
Isetta et al. [25] 1993 France NR HD APR (n = 70) vs. LD APR (n = 70) vs. TXA (n = 70) vs. Control (n = 70)
Blauhut et al. [27] 1994 Switzerland CABG HD APR (n = 14) vs. TXA (n = 14) vs. Control (n = 14)
Penta de Peppo et al. [20] 1995 Italy CABG & Valve Sx. HD APR (n = 15) vs. TXA (n = 15) vs. EACA (n = 15) vs. Control (n = 15)
Corbeau et al. [23] 1995 France CABG & Valve Sx. HD APR (n = 43) vs. TXA (n = 41) vs. Control (n = 20)
Pugh et al. [22] 1995 UK Primary CABG LD APR (n = 21) vs. TXA (n = 22) vs. Control (n = 23)
Speekenbrink et al. [21] 1995 The Netherlands Primary CABG PP APR (n = 15) vs. TXA (n = 15) vs. DIP (n = 12) vs. Control (n = 15)
Menichetti et al. [24] 1996 Italy Primary CABG HD APR (n = 24) vs. TXA (n = 24) vs. EACA (n = 24) vs. Control (n = 24)
Pinosky et al. [33] 1997 USA Primary CABG TXA (n = 20) vs. EACA (n = 20) vs. Placebo (n = 19)
Mongan et al. [31] 1998 USA Primary CABG HD APR (n = 75) vs. TXA (n = 75)
Hardy et al. [26] 1998 Canada Primary CABG TXA (n = 42) vs. EACA (n = 46) vs. Placebo (n = 44)
Eberle et al. [29] 1998 Germany Primary CABG HD APR (n = 20) vs. EACA (n = 20)
Misfeld et al. [30] 1998 Germany Primary CABG LD APR (n = 14) vs. TXA (n = 14) vs. Control (n = 14)
Casati et al. [28] 1999 Italy Primary CABG & Valve Sx. HD APR (n = 67) vs. TXA (n = 70) vs. EACA (n = 66)
Bernet et al. [34] 1999 Switzerland Primary CABG HD APR (n = 28) vs. TXA (n = 28)
Nuttall et al. [32] 2000 USA Re-do CABG & Valve Sx. HD APR (n = 40) vs. TXA (n = 45) vs. TXA+ANH (n = 32) vs Placebo (n = 43)
Maineri et al. [38] 2000 Italy Primary CABG TXA (n = 24) vs. EACA (n = 24)
Wong et al. [37] 2000 Canada Re-do CABG & Valve Sx. HD APR (n = 39) vs. TXA (n = 38)
Casati et al. [35] 2000 Italy Primary CABG & Valve & ASD Repair HD APR (n = 518) vs. TXA (n = 522)
Greilich et al. [36] 2001 USA Primary CABG HD APR (n = 24) vs. EACA (n = 23) vs. Placebo (n = 25)
Ray et al. [6] 2001 Australia CABG & Valve Sx. LD APR (n = 49) vs. EACA (n = 51)
  1. ANH = acute normovolemic hemodilution, APR = aprotinin, ASD = atrial septal defect, CABG = coronary artery bypass graft, DIP = dipyridamole, EACA = epsilon aminocaproic acid, HD = high dose, LD = low dose, NR = not reported, PP = pump prime, Sx. = surgery, TXA = tranexamic acid