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Table 3 Distribution of factors and relation to cardiovascular events during follow-up and partly and fully adjusted hazard ratios for cardiovascular events associated with Interleukin-1 receptor antagonist gene polymorphisms (IL-1RA) and serostatus of CMV

From: Prognostic value of interleukin-1 receptor antagonist gene polymorphism and cytomegalovirus seroprevalence in patients with coronary artery disease

Factor CVD-events during follow-up, row % (ap-value) bPartly-adjusted hazard ratio (95% confidence interval) cFully-adjusted hazard ratio (95% confidence interval)
IL-1 RA    
- otherd 20.4% 1reference 1reference
- Il-1RN*2 16.3% (0.73) 1.1 (0.80–1.66) 1.03 (0.60–1.76)
CMV-serostatus    
- negative 20.7% 1reference 1reference
- positive   0.91 (0.55–1.52) 1.00 (0.59–1.72)
   - positive, titre < median 16.7% 0.74 (0.38–1.43) 0.78 (0.40–1.54)
   - positive titre ≥ median 22.1% (0.54) 1.12 (0.61–2.05) 1.32 (0.69–2.52)
IL-1 RA and CMV serostatus    
- IL-otherd and CMV-negative 21.9% 1reference 1reference
- IL-otherd and CMV-positive 19.1% 0.86 (0.50–1.45) 0.94 (0.54–1.64)
- Il-1RN*2 and CMV-negative 12.5% 0.56 (0.13–2.36) 0.37 (0.08 – 1.67)
- Il-1RN*2 and CMV-positive 21.4% (0.83) 0.96 (0.32–3.43) 0.95 (0.27 – 3.38)
  1. a = according to log-rank test
  2. b = adjusted for age and gender
  3. c = adjusted for age, gender, body mass index, school education, cigarette smoking, alcohol consumption, history of myocardial infarction, history of hypertension, history of diabetes, statin intake, intake of aspirin, intake of diuretics
  4. d = all other alleles
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