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Table 1 Baseline characteristics of the studies included in the meta-analysis

From: The preventive effect of atorvastatin on atrial fibrillation: a meta-analysis of randomized controlled trials

Study, year n Population Dosage Duration Endpoint Documentation of AF Quality score
MIRACL 2004 [13] 3087 Acute coronary syndrome 80 mg/d 16 weeks New onset or recurrence of AF Follow-up with ECG 5
Dernellis et al. 2005 [14] 80 Paroxysmal AF 20–40 mg/d 4–6 months Recurrence of AF 48-h ambulatory ECG monitoring 3
Chello et al. 2006 [15] 40 Coronary bypass surgery 20 mg/d 3 weeks New-onset AF after cardiac surgery ECG monitoring 4
Ozaydin et al. 2006 [16] 48 Persistent AF and scheduled EC 10 mg/d 3 months Recurrence of AF 24-h ambulatory ECG monitoring 2
ARMYDA-3 2006 [17] 200 Cardiac surgery 40 mg/d 30 days New-onset AF after cardiac surgery ECG monitoring after the operation, then follow-up with ECG 5
Tsai et al. 2008 [18] 106 Bradyarrhythmia and implantation of pacemaker 20 mg/d 1 year AF/AHE ≥ 10 min Pacemaker interrogation 2
Song et al. 2008 [19] 124 Off-pump coronary bypass surgery 20 mg/d 30 days New-onset AF after cardiac surgery ECG monitoring after the operation, then follow-up with ECG 3
Almroth et al. 2009 [20] 234 Persistent AF and scheduled EC 80 mg/d 30 days Recurrence of AF Follow-up with ECG 5
Melina et al. 2009 [21] 632 Coronary bypass surgery 40 mg/d Not mentioned New-onset AF after cardiac surgery Not mentioned 2
Ji et al. 2009 [22] 140 Off-pump coronary bypass surgery 20 mg/d 13 days New-onset AF after cardiac surgery ECG monitoring or 12-lead ECG 5
Spadaccio et al. 2010 [23] 50 Coronary bypass surgery 20 mg/d 7 days New-onset AF after cardiac surgery ECG monitoring 4
Sun et al. 2011 [24] 100 Coronary bypass surgery 20 mg/d 14 days New-onset AF after cardiac surgery ECG monitoring 3
SToP AF 2011 [25] 64 Persistent AF and scheduled EC 80 mg/d 12 months Recurrence of AF Follow-up with ECG and 24-h ambulatory ECG monitoring 5
SPARCL 2011 [26] 4731 Prior stroke or transient ischemic attack 80 mg/d 4.8 years New-onset AF Follow-up with ECG 5
Demir et al. 2011 [27] 48 Persistent AF and scheduled EC 40 mg/d 2 months Recurrence of AF Weekly follow-up with ECG 2
Baran et al. 2012 [28] 60 Coronary bypass surgery 40 mg/d 30 days New-onset AF after cardiac surgery ECG monitoring after the operation, then follow-up with ECG 5
Suleiman et al. 2012 [29] 125 AF undergoing catheter ablation 80 mg/d 3 months Recurrence of AF Follow-up with ECG and 72-h ambulatory ECG monitoring 4
Jiang et al. 2013 [30] 101 AF undergoing catheter ablation 40 mg/d 6 months Recurrence of AF Not mentioned 2
  1. AF: atrial fibrillation; AHE: Atrial high rate episode; ARMYDA-3: Atorvastatin for Reduction of MYocardial Dysrhythmia After cardiac surgery study; EC: Electrical cardioversion; ECG: Electrocardiogram; MIRACL: Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering study; SPARCL: Stroke Prevention by Aggressive Reduction in Cholesterol Levels; SToP AF: statin therapy for the prevention of atrial fibrillation trial.