Table 1 Model input parameters

Costs & event occurrence

Cost of conventional cTnT test

€17.11(12.8-21.4)

Beta PERT

Commercial price at MUMC

Cost of new hsTnT test

€31.5 (23.6-39.4)

Beta PERT

Time & motion study*

Cost of AMI in 1^st year

€ 12446 ( 9334–15557)

GAMMA

[21]

Cost of AMI in subsequent year

€ 2092 (1569–2615)

GAMMA

[21]

Utility score for AMI

0.725 (0.544-0.906)

BETA

[19]

Discount rate: cost

0.4

Fixed

[23]

Discount rate: Effect

0.15

Fixed

[23]

Prevalence of AMI among patients presenting with chest pain

0.30 (0.23 -0.38)

Beta PERT

[5]

Risk adjusted mortality ratio among inappropriately discharged AMI patients

1.9 (1.43 -2.38)

Beta PERT

[20]

Life expectancy of AMI survivor (years)

8.3 (6.23-10.38)

Beta PERT

[16]

Diagnostic accuracy

[17]

cTnT sensitivity at ≤6 hours

0.44 (0.32-0.56)

BETA

cTnT sensitivity at ≤12 hours

0.93 (0.85-0.97)

BETA

cTnT specificity at ≤6 hours

0.92 (0.88-0.95)

BETA

cTnT specificity at ≤12 hours

0.85 (0.76-0.91)

BETA

hsTnT sensitivity at ≤6 hours

0.94 (0.87-0.98)

BETA

hsTnT sensitivity at ≤12 hours

0.95 (0.91-0.98)

BETA

hsTnT specificity at ≤6 hours

0.52 (0.39-0.65)

BETA

hsTnT specificity at ≤12 hours

0.51 (0.40-0.62)

BETA

hsTnT + hFABP sensitivity at ≤6 hours

0.97 (0.90-0.99)

BETA

hsTnT + hFABP sensitivity at ≤12 hours

0.97 (0.93-0.99)

BETA

hsTnT + hFABP specificity at ≤ 6 hours

0.39 (0.27-0.51)

BETA

hsTnT + hFABP specificity at ≤ 12 hours

0.38 (0.27-0.49)

BETA

Event occurrence

Average of AMI mortality among patients given PPCI within 4 hours of presentation

0.062 (0.0468-0.0780)

Beta PERT

Calculated from [3]

AMI mortality among patients given PPCI after 4 hours of presentation

0.103 (0.077-0.1288)

Beta PERT

[3]

PPCI procedure related mortality

0.0072 (0.0054-0.009)

Beta PERT

[18]