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Table 1 Model input parameters

From: High-sensitive Troponin T assay for the diagnosis of acute myocardial infarction: an economic evaluation

Parameter Deterministic values (min – max range) Distribution Source
Costs & event occurrence    
Cost of conventional cTnT test €17.11(12.8-21.4) Beta PERT Commercial price at MUMC
Cost of new hsTnT test €31.5 (23.6-39.4) Beta PERT Time & motion study*
Cost of AMI in 1st year € 12446 ( 9334–15557) GAMMA [21]
Cost of AMI in subsequent year € 2092 (1569–2615) GAMMA [21]
Utility score for AMI 0.725 (0.544-0.906) BETA [19]
Discount rate: cost 0.4 Fixed [23]
Discount rate: Effect 0.15 Fixed [23]
Prevalence of AMI among patients presenting with chest pain 0.30 (0.23 -0.38) Beta PERT [5]
Risk adjusted mortality ratio among inappropriately discharged AMI patients 1.9 (1.43 -2.38) Beta PERT [20]
Life expectancy of AMI survivor (years) 8.3 (6.23-10.38) Beta PERT [16]
Diagnostic accuracy    [17]
cTnT sensitivity at ≤6 hours 0.44 (0.32-0.56) BETA
cTnT sensitivity at ≤12 hours 0.93 (0.85-0.97) BETA
cTnT specificity at ≤6 hours 0.92 (0.88-0.95) BETA
cTnT specificity at ≤12 hours 0.85 (0.76-0.91) BETA
hsTnT sensitivity at ≤6 hours 0.94 (0.87-0.98) BETA
hsTnT sensitivity at ≤12 hours 0.95 (0.91-0.98) BETA
hsTnT specificity at ≤6 hours 0.52 (0.39-0.65) BETA
hsTnT specificity at ≤12 hours 0.51 (0.40-0.62) BETA
hsTnT + hFABP sensitivity at ≤6 hours 0.97 (0.90-0.99) BETA
hsTnT + hFABP sensitivity at ≤12 hours 0.97 (0.93-0.99) BETA
hsTnT + hFABP specificity at ≤ 6 hours 0.39 (0.27-0.51) BETA
hsTnT + hFABP specificity at ≤ 12 hours 0.38 (0.27-0.49) BETA
Event occurrence   
Average of AMI mortality among patients given PPCI within 4 hours of presentation 0.062 (0.0468-0.0780) Beta PERT Calculated from [3]
AMI mortality among patients given PPCI after 4 hours of presentation 0.103 (0.077-0.1288) Beta PERT [3]
PPCI procedure related mortality 0.0072 (0.0054-0.009) Beta PERT [18]
  1. *Time & Motion study done at Pathology Laboratory, MUMC.