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Table 3 Associations and predictive accuracies (95% CIs) for indicators of risk predicting disease incidence (age-adjusted models)

From: Validation of continuous clinical indices of cardiometabolic risk in a cohort of Australian adults

 

CVD

T2DM

CM disease

 

AUC

TPR1

FPR2

OR

AUC

TPR1

FPR2

OR

AUC

TPR1

FPR2

OR

Men

n = 1124

n = 934

n = 835

MetS 3

-

0.41

0.27

1.90

-

0.52

0.22

3.72

-

0.42

0.21

2.69

(0.32–0.50)

(0.24–0.29)

(1.31–2.78)

(0.42–0.61)

(0.20–0.25)

(2.46–5.63)

(0.34–0.50)

(0.18–0.24)

(1.86–3.89)

cCICR-Z

0.73

0.54

0.16

1.62

0.76

0.59

0.17

2.48

0.75

0.50

0.15

2.03

(0.69–0.77)

(0.44–0.64)

(0.08–0.24)

(1.33–1.99)

(0.71–0.81)

(0.49–0.70)

(0.11–0.23)

(1.90–3.25)

(0.71–0.79)

(0.40–0.59)

(0.10–0.20)

(1.62–2.55)

cCICR-PCA

0.73

0.59

0.15

1.65

0.75

0.60

0.20

2.32

0.75

0.54

0.16

2.01

(0.69–0.78)

(0.49–0.69)

(0.09–0.22)

(1.35–2.03)

(0.71–0.80)

(0.48–0.73)

(0.16–0.25)

(1.79–3.00)

(0.71–0.79)

(0.44–0.63)

(0.12–0.20)

(1.61–2.51)

F-CVD

0.73

0.55

0.16

2.45

-

-

-

-

0.72

0.49

0.16

2.71

(0.69–0.77)

(0.46–0.65)

(0.10–0.22)

(1.63–3.68)

(0.68–0.77)

(0.40–0.58)

(0.11–0.22)

(1.78–4.13)

F-T2DM

-

-

-

-

0.79

0.68

0.15

2.27

0.75

0.54

0.15

1.81

     

(0.74–0.83)

(0.57–0.79)

(0.09–0.20)

(1.84–2.80)

(0.71–0.79)

(0.45–0.64)

(0.08–0.21)

(1.51–2.16)

Women

n = 1348

n = 1091

n = 1024

MetS 3

-

0.27

0.19

1.54

-

0.40

0.13

4.21

-

0.28

0.13

2.68

(0.19–0.36)

(0.17–0.22)

(1.01–2.35)

(0.30–0.49)

(0.11–0.16)

(2.69–6.58)

(0.21–0.34)

(0.11–0.15)

(1.80–3.99)

cCICR-Z

0.76

0.57

0.06

1.24

0.73

0.40

0.14

2.04

0.74

0.43

0.06

1.66

(0.71–0.80)

(0.47–0.66)

(0.03–0.09)

(1.03–1.51)

(0.68–0.79)

(0.28–0.52)

(0.09–0.19)

(1.62–2.58)

(0.69–0.78)

(0.35–0.52)

(0.03–0.09)

(1.37–2.02)

cCICR–PCA

0.76

0.58

0.06

1.28

0.73

0.35

0.14

1.97

0.73

0.43

0.06

1.63

(0.72–0.80)

(0.49–0.68)

(0.02–0.09)

(1.05–1.56)

(0.67–0.78)

(0.24–0.47)

(0.09–0.19)

(1.56–2.48)

(0.69–0.78)

(0.34–0.52)

(0.04–0.09)

(1.34–1.97)

F-CVD

0.76

0.56

0.08

1.59

-

-

-

-

0.72

0.42

0.08

1.84

(0.72–0.80)

(0.46–0.65)

(0.05–0.10)

(1.07–2.35)

(0.67–0.76)

(0.32–0.51)

(0.05–0.11)

(1.25–2.69)

F-T2DM

-

-

-

-

0.75

0.46

0.09

2.00

0.74

0.41

0.07

1.63

(0.70–0.81)

(0.35–0.56)

(0.05–0.14)

(1.65–2.42)

(0.70–0.78)

(0.32–0.50)

(0.04–0.11)

(1.38–1.93)

  1. 1TPR with FPR fixed at MetS levels; 2FPR with TPR fixed at MetS levels; 3not age-adjusted.
  2. Abbreviations: CVD Cardiovascular disease, T2DM Type 2 diabetes, CM Cardiometabolic, AUC Area under the curve, TPR True positive rate, FPR False positive rate, OR Odds ratio, MetS Metabolic syndrome, cCICR-Z Continuous clinical index of cardiometabolic risk constructed as the mean of standardised risk scores, cCICR-PCA Continuous clinical index of cardiometabolic risk constructed using principal component analysis, F-CVD Framingham 10-year General CVD Risk Score, FT2DM Framingham 8-year Diabetes Risk Score.
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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