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Table 4 Physiological values of AMSA during 15 minutes of MCC-time

From: Repeated epinephrine doses during prolonged cardiopulmonary resuscitation have limited effects on myocardial blood flow: a randomized porcine study

 

AMSA NaCl

AMSA EPI All

P-value

AMSA EPI 0.02 mg/kg/dose

P-value

AMSA EPI 0.03 mg/kg/dose

P-value

MCC 20 s

12.1

(9.6-14.0)b

13.0

(10.9-16.0)d

0.4099

13.0

(11.8-13.0)c

0.3913

13.1

(10.6-15.0)a

0.5752

MCC 60 s

12.4

(10.8-15.3)b

14.4

(11.4-16.8)d

0.4990

13.7

(10.8-17.6)c

0.7751

14.6

(13.0-15.8)a

0.4288

MCC 120 s

13.8

(12.1-16.3)b

16.0

(14.2-18.7)d

0.1974

16.0

(14.2-19.8)c

0.1779

15.5

(13.8-17.6)a

0.3734

MCC 180 s

14.7

(13.3-17.9)b

17.0

(12.8-19.0)d

0.3749

17.0

(12.8-19.3)c

0.4877

17.0

(15.3-18.3)a

0.4288

Inj #1

14.3

(12.7-16.8)b

15.9

(13.9-16.7)d

0.4725

15.4

(9.7-16.7)c

0.4142

16.1

(13.3-16.7)a

0.6682

Peak #1

14.7

(11.5-15.9)b

14.6

(13.0-16.2)d

0.6121

14.6

(13.8-15.9)c

0.7133

14.7

(12.7-16.2)a

0.6444

Inj #2

13.9

(11.0-15.4)b

14.0

(11.6-14.5)d

0.8824

14.3

(13.0-14.9)c

0.7751

13.8

(11.6-14.3)a

0.6209

Peak #2

13.5

(10.4-14.7)b

12.5

(11.0-14.6)d

1.0000

13.1

(11.9-17.5)c

0.5956

12.2

(10.4-13.9)a

0.6682

Inj #3

13.7

(11.4-14.8)b

11.5

(9.7-13.8)d

0.2285

11.5

(10.2-20.9)c

0.5676

11.2

(9.5-11.7)a

0.1616

Peak #3

12.7

(10.6-15.5)b

12.5

(11.1-14.5)d

0.9831

13.1

(10.2-20.9)c

0.5954

12.2

(11.3-14.3)a

0.7169

Inj # 4

13.9

(11.3-15.3)b

11.0

(9.7-13.5)d

0.1696

11.8

(10.5-14.3)c

0.6534

10.6

(8.8-12.2)a

0.0806

Peak #4

14.0

(11.4-15.3)e

11.0

(8.9-15.9)d

0.8841

16.8

(9.9-11.1)c

0.3165

9.9

(8.8-14.3)a

0.2814

  1. AMSA = amplitude spectral area (mV · Hz), NaCl = saline, EPI = epinephrine, MCC = Mechanical chest compressions, Inj = injection, a: n = 12, b: n = 10, c: n = 9, d: n = 21, e: n = 6. Peak values at 20 , 60, 120, 180 seconds after start of MCC, at each time point of the 4 drug injections (4, 7, 10, 13 minutes after start of MCC) and the corresponding peak to each injection for NaCl compared to EPI. All values are expressed as median, 25th and 75th interquartile.