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Table 2 Physiological values of CPP during 15 minutes of MCC-time

From: Repeated epinephrine doses during prolonged cardiopulmonary resuscitation have limited effects on myocardial blood flow: a randomized porcine study

 

CPP NaCl (n = 12)

CPP EPI all (n = 24)

P-value

CPP EPI 0.02 mg/kg/dose (n = 12)

P-value

CPP EPI 0.03 mg/dose (n = 12)

P-value

MCC 20 s

30

(23-42)a

27

(12-40)e

0.4141

28

(12-46)b

0.7818

26

(18-37)a

0.2855

MCC 60 s

31

(23-36)a

25

(16-45)d

0.9331

34

(14-46)a

0.6650

25

(21-46)a

0.7950

MCC 120 s

28

(14-36)a

27

(9-47)e

0.7152

25

(16-49)b

0.5588

29

(25-52)b

0.6891

MCC 180 s

29

(14-39)a

27

(13-42)f

0.8712

25

(14-44)b

1.0000

29

(21-53)c

0.9737

Inj #1

29

(10-40)b

27

(11-49)n

0.9368

31

(11-48)b

0.9476

27

(14-57)c

0.9719

Peak #1

29

(11-41)c

44

(31-78)e

0.0219

38

(28-78)b

0.1489

47

(39-77)a

0.0134

Inj #2

29

(15-41)b

25

(16-38)e

1.0000

19

(10-44)a

0.6009

27

(24-50)b

0.5545

Peak #2

28

(12-36)c

39

(31-59)e

0.0160

50

(31-65)a

0.0229

37

(29-56)b

0.0620

Inj #3

32

(18-35)c

27

(11-36)d

0.9849

12

(7-38)a

0.6209

27

(25-39)a

0.6682

Peak #3

28

(10-38)c

39

(29-50)e

0.1434

42

(32-50)a

0.0265

35

(28-64)a

0.1213

Inj # 4

31

(21-32)b

26

(12-38)f

0.9848

13

(11-43)c

0.5974

27

(23-39)a

0.6891

Peak #4

24

10-37)c

32

(24-45)e

0.1894

32

(22-47)b

0.2453

33

(29-44)a

0.2766

  1. CPP = Coronary perfusion pressure (mmHg), NaCl = Saline, EPI = epinephrine, MCC = Mechanical chest compressions, Inj = injection, a: n = 12, b: n = 11, c: n = 10, d: n = 24, e: n = 23, f: n = 22, g: n = 21. Peak values at 20 , 60, 120, 180 seconds after start of MCC, at each time point of the 4 drug injections (4, 7, 10, 13 minutes after start of MCC) and the corresponding peak to each injection for NaCl compared to EPI. All values are expressed as median, 25th and 75th interquartile.