Skip to main content

Table 3 Subgroup analysis for the effect of statin therapy on total mortality

From: Effect of statins on cardiovascular events in patients with mild to moderate chronic kidney disease: a systematic review and meta-analysis of randomized clinical trials

Subgroup

Value

Reference

Statin

Control

Relative risk (95% CI)

p value

Heterogeneity

p value for heterogeneity

   

Event/total

Event/total

    

Mean Age

> = 60

23

183/3211

267/3251

0.71[0.59,0.84]

<0.001

0%

0.52

 

<60

28,29,31,33

698/8376

873/8448

0.81[0.73,0.89]

<0.001

-

-

Cardiovascular History

Yes

28,29,31,34

235/2417

317/11689

1.48[0.41,5.36]

0.550

98.1%

<0.001

 

No

26

40/3533

63/3663

0.66[0.44,0.98]

0.037

-

-

Baseline GFR

> = 60

23,26,28

837/13046

1082/13280

0.78[0.72,0.85]

<0.001

0%

0.42

 

<60

29,33

47/286

59/293

0.68[0.47,1.00]

0.050

49.8%

0.16

Baseline Creatinine

> = 1.5

23,28,31

47/286

59/293

0.82[0.58,1.15]

0.251

-

-

 

<1.5

29

800/9663

1022/9777

0.79[0.73,0.87]

<0.001

0%

0.58

Baseline Total Cholesterol

> = 5.0

29,31,33,34

797/9513

1017/9617

0.75[0.62,0.90]

0.002

0%

0.45

 

<5.0

23,28

282/4520

347/4454

0.79[0.67,0.93]

<0.001

0%

0.33

Baseline LDL Cholesterol

> = 3.0

23,28-29,31,34

933/10793

1192/10937

0.79[0.73,0.86]

<0.001

0%

0.89

 

<3.0

33

34/1638

61/1629

0.55[0.37,0.84]

0.005

-

-

Follow-up time

> = 3

23,26,28,29,31,34

973/14326

1255/14600

0.79[0.73,0.85]

<0.001

0%

0.86

 

<3

33

34/1638

61/1629

0.55[0.37,0.84]

0.005

-

-

  1. Abbreviations: CI confidential interval, GFR glomerular filtration rate, LDL low density lipoprotein.