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Table 3 Subgroup analysis for the effect of statin therapy on total mortality

From: Effect of statins on cardiovascular events in patients with mild to moderate chronic kidney disease: a systematic review and meta-analysis of randomized clinical trials

Subgroup Value Reference Statin Control Relative risk (95% CI) p value Heterogeneity p value for heterogeneity
    Event/total Event/total     
Mean Age > = 60 23 183/3211 267/3251 0.71[0.59,0.84] <0.001 0% 0.52
  <60 28,29,31,33 698/8376 873/8448 0.81[0.73,0.89] <0.001 - -
Cardiovascular History Yes 28,29,31,34 235/2417 317/11689 1.48[0.41,5.36] 0.550 98.1% <0.001
  No 26 40/3533 63/3663 0.66[0.44,0.98] 0.037 - -
Baseline GFR > = 60 23,26,28 837/13046 1082/13280 0.78[0.72,0.85] <0.001 0% 0.42
  <60 29,33 47/286 59/293 0.68[0.47,1.00] 0.050 49.8% 0.16
Baseline Creatinine > = 1.5 23,28,31 47/286 59/293 0.82[0.58,1.15] 0.251 - -
  <1.5 29 800/9663 1022/9777 0.79[0.73,0.87] <0.001 0% 0.58
Baseline Total Cholesterol > = 5.0 29,31,33,34 797/9513 1017/9617 0.75[0.62,0.90] 0.002 0% 0.45
  <5.0 23,28 282/4520 347/4454 0.79[0.67,0.93] <0.001 0% 0.33
Baseline LDL Cholesterol > = 3.0 23,28-29,31,34 933/10793 1192/10937 0.79[0.73,0.86] <0.001 0% 0.89
  <3.0 33 34/1638 61/1629 0.55[0.37,0.84] 0.005 - -
Follow-up time > = 3 23,26,28,29,31,34 973/14326 1255/14600 0.79[0.73,0.85] <0.001 0% 0.86
  <3 33 34/1638 61/1629 0.55[0.37,0.84] 0.005 - -
  1. Abbreviations: CI confidential interval, GFR glomerular filtration rate, LDL low density lipoprotein.