Figure 4

Proposed hypothesis--in-stent restenosis, diabetes, thiazolidinedione use, adiponectin, and vascular smooth muscle cell phenotype. The panel on the left proposes that diabetics are at increased risk for in-stent restenosis due to lower adiponectin levels increasing the likelihood that vascular smooth muscle cells (VSMCs) will adopt the proliferative phenotype. The panel on the right proposes that diabetics taking thiazolidinediones (TZDs) have higher adiponectin levels increasing the likelihood that vascular smooth muscle cells (VSMCs) will adopt the quiescent phenotype which decreases the chance of developing in-stent restenosis.